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Page 1
First evidence of a serine arginine protein kinase (SRPK) in leishmania braziliensis and its potential as therapeutic target.
Pimentel DC, Leopoldo JR, Teixeira LF, Barros MVA, de Souza APM, Onofre TS, de Carvalho RL, Machado SA, Messias IG, Pinto CCS, Poleto MD, Diogo MA, Mariotini-Moura C, Bressan GC, Teixeira RR, Fietto JLR, Vasconcellos RS. Pimentel DC, et al. Among authors: de souza apm. Acta Trop. 2023 Feb;238:106801. doi: 10.1016/j.actatropica.2022.106801. Epub 2022 Dec 20. Acta Trop. 2023. PMID: 36563831
Immunomodulatory activity of trifluoromethyl arylamides derived from the SRPK inhibitor SRPIN340 and their potential use as vaccine adjuvant.
Mendes FC, de Paiva JC, da Silva EQG, Santos MR, de Almeida Lima GD, Moreira GA, Silva LVG, de Melo Agripino J, de Souza APM, de Oliveira Mendes TA, Machado-Neves M, Teixeira RR, Silva-Júnior A, Fietto JLR, de Oliveira LL, Bressan GC. Mendes FC, et al. Among authors: de souza apm. Life Sci. 2022 Oct 15;307:120849. doi: 10.1016/j.lfs.2022.120849. Epub 2022 Aug 1. Life Sci. 2022. PMID: 35926588 Free article.
The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice.
Moreira GA, Caetano MMM, do Vale JA, de Paiva JC, Gonçalves VHS, Almeida AA, Silva LVG, Martim FRG, de Andrade Barros MV, Guimarães GR, de Oliveira Santos L, de Souza APM, Machado-Neves M, Teixeira RR, Silva-Júnior A, Fietto JLR, Boroni M, de Oliveira LL, Bressan GC. Moreira GA, et al. Among authors: de souza apm. Biochem Pharmacol. 2022 Sep;203:115161. doi: 10.1016/j.bcp.2022.115161. Epub 2022 Jul 2. Biochem Pharmacol. 2022. PMID: 35787994 Free article.
Effect of the topical administration of N-(2-(4-bromophenylamino)-5-(trifluoromethyl)phenyl)nicotinamide compound in a murine subcutaneous melanoma model.
Vale JAD, de Souza APM, Lima GDA, Gonçalves VHS, Moreira GA, Barros MVA, Pereira WL, Merchid NCLE, Fietto JLR, Bressan GC, Teixeira RR, Machado-Neves M. Vale JAD, et al. Among authors: de souza apm. Anticancer Drugs. 2020 Aug;31(7):718-727. doi: 10.1097/CAD.0000000000000944. Anticancer Drugs. 2020. PMID: 32568827
Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells.
Siqueira RP, Caetano MMM, de Souza LÂ, Dos Passos PMS, Simaroli NB, Barros MVA, de Souza APM, de Oliveira LL, Silva-Júnior A, Fietto JLR, Teixeira RR, Teixeira FR, Bressan GC. Siqueira RP, et al. Among authors: de souza apm. Toxicol In Vitro. 2020 Jun;65:104777. doi: 10.1016/j.tiv.2020.104777. Epub 2020 Jan 18. Toxicol In Vitro. 2020. PMID: 31962201 Free article.
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease.
Oliveira AFCDS, de Souza APM, de Oliveira AS, da Silva ML, de Oliveira FM, Santos EG, da Silva ÍEP, Ferreira RS, Villela FS, Martins FT, Leal DHS, Vaz BG, Teixeira RR, de Paula SO. Oliveira AFCDS, et al. Among authors: de souza apm. Eur J Med Chem. 2018 Apr 10;149:98-109. doi: 10.1016/j.ejmech.2018.02.037. Epub 2018 Feb 22. Eur J Med Chem. 2018. PMID: 29499491
Occurrence and risk assessment of population exposed to deoxynivalenol in foods derived from wheat flour in Brazil.
Silva MV, Pante GC, Romoli JCZ, de Souza APM, Rocha GHOD, Ferreira FD, Feijó ALR, Moscardi SMP, de Paula KR, Bando E, Nerilo SB, Machinski M Jr. Silva MV, et al. Among authors: de souza apm. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Mar;35(3):546-554. doi: 10.1080/19440049.2017.1411613. Epub 2017 Dec 28. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018. PMID: 29210608