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A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer.
de Sousa e Melo F, Kurtova AV, Harnoss JM, Kljavin N, Hoeck JD, Hung J, Anderson JE, Storm EE, Modrusan Z, Koeppen H, Dijkgraaf GJ, Piskol R, de Sauvage FJ. de Sousa e Melo F, et al. Among authors: de sauvage fj. Nature. 2017 Mar 29;543(7647):676-680. doi: 10.1038/nature21713. Nature. 2017. PMID: 28358093
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Vermeulen L, et al. Among authors: de sousa e melo f, de jong jh. Nat Cell Biol. 2010 May;12(5):468-76. doi: 10.1038/ncb2048. Epub 2010 Apr 25. Nat Cell Biol. 2010. PMID: 20418870
Cancer stem cell niche: the place to be.
Borovski T, De Sousa E Melo F, Vermeulen L, Medema JP. Borovski T, et al. Among authors: de sousa e melo f. Cancer Res. 2011 Feb 1;71(3):634-9. doi: 10.1158/0008-5472.CAN-10-3220. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266356 Free article. Review.
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
De Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LP, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJ, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L. De Sousa E Melo F, et al. Among authors: de jong jh, de boer oj, de rooij lp. Nat Med. 2013 May;19(5):614-8. doi: 10.1038/nm.3174. Epub 2013 Apr 14. Nat Med. 2013. PMID: 23584090
Isolation and propagation of colon cancer stem cells.
Prasetyanti PR, Zimberlin C, De Sousa E Melo F, Medema JP. Prasetyanti PR, et al. Among authors: de sousa e melo f. Methods Mol Biol. 2013;1035:247-59. doi: 10.1007/978-1-62703-508-8_21. Methods Mol Biol. 2013. PMID: 23959997
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.
Storm EE, Durinck S, de Sousa e Melo F, Tremayne J, Kljavin N, Tan C, Ye X, Chiu C, Pham T, Hongo JA, Bainbridge T, Firestein R, Blackwood E, Metcalfe C, Stawiski EW, Yauch RL, Wu Y, de Sauvage FJ. Storm EE, et al. Among authors: de sousa e melo f, de sauvage fj. Nature. 2016 Jan 7;529(7584):97-100. doi: 10.1038/nature16466. Epub 2015 Dec 23. Nature. 2016. PMID: 26700806
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss.
Hoeck JD, Biehs B, Kurtova AV, Kljavin NM, de Sousa E Melo F, Alicke B, Koeppen H, Modrusan Z, Piskol R, de Sauvage FJ. Hoeck JD, et al. Among authors: de sousa e melo f, de sauvage fj. Nat Cell Biol. 2017 Jun;19(6):666-676. doi: 10.1038/ncb3535. Epub 2017 May 29. Nat Cell Biol. 2017. PMID: 28553937
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN. Nile AH, et al. Among authors: de sousa e melo f, de sauvage fj. Nat Chem Biol. 2018 Jun;14(6):582-590. doi: 10.1038/s41589-018-0035-2. Epub 2018 Apr 9. Nat Chem Biol. 2018. PMID: 29632413
Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN. Nile AH, et al. Among authors: de sousa e melo f, de sauvage fj. Nat Chem Biol. 2018 Sep;14(9):902. doi: 10.1038/s41589-018-0069-5. Nat Chem Biol. 2018. PMID: 29728602
39 results