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Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.
Jardim GAM, Silva TL, Goulart MOF, de Simone CA, Barbosa JMC, Salomão K, de Castro SL, Bower JF, da Silva Júnior EN. Jardim GAM, et al. Among authors: de castro sl, de simone ca. Eur J Med Chem. 2017 Aug 18;136:406-419. doi: 10.1016/j.ejmech.2017.05.011. Epub 2017 May 4. Eur J Med Chem. 2017. PMID: 28521262
Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and resistant strains of Mycobacterium tuberculosis.
Reis WJ, Bozzi ÍAO, Ribeiro MF, Halicki PCB, Ferreira LA, Almeida da Silva PE, Ramos DF, de Simone CA, da Silva Júnior EN. Reis WJ, et al. Among authors: de simone ca. Bioorg Med Chem. 2019 Sep 15;27(18):4143-4150. doi: 10.1016/j.bmc.2019.07.045. Epub 2019 Jul 27. Bioorg Med Chem. 2019. PMID: 31378595 Free article.
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
da Cruz EHG, Silvers MA, Jardim GAM, Resende JM, Cavalcanti BC, Bomfim IS, Pessoa C, de Simone CA, Botteselle GV, Braga AL, Nair DK, Namboothiri INN, Boothman DA, da Silva Júnior EN. da Cruz EHG, et al. Among authors: de simone ca. Eur J Med Chem. 2016 Oct 21;122:1-16. doi: 10.1016/j.ejmech.2016.06.019. Epub 2016 Jun 14. Eur J Med Chem. 2016. PMID: 27341379 Free PMC article.
Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.
Baiju TV, Almeida RG, Sivanandan ST, de Simone CA, Brito LM, Cavalcanti BC, Pessoa C, Namboothiri INN, da Silva Júnior EN. Baiju TV, et al. Among authors: de simone ca. Eur J Med Chem. 2018 May 10;151:686-704. doi: 10.1016/j.ejmech.2018.03.079. Epub 2018 Apr 5. Eur J Med Chem. 2018. PMID: 29660689
Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications.
Almeida RG, Valença WO, Rosa LG, de Simone CA, de Castro SL, Barbosa JMC, Pinheiro DP, Paier CRK, de Carvalho GGC, Pessoa C, Goulart MOF, Kharma A, da Silva Júnior EN. Almeida RG, et al. Among authors: de simone ca. RSC Med Chem. 2020 Jul 13;11(10):1145-1160. doi: 10.1039/d0md00072h. eCollection 2020 Oct 1. RSC Med Chem. 2020. PMID: 33479619 Free PMC article.
On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
da Silva Júnior EN, de Melo IM, Diogo EB, Costa VA, de Souza Filho JD, Valença WO, Camara CA, de Oliveira RN, de Araujo AS, Emery FS, dos Santos MR, de Simone CA, Menna-Barreto RF, de Castro SL. da Silva Júnior EN, et al. Among authors: de castro sl, de melo im, de araujo as, de simone ca, de souza filho jd, de oliveira rn. Eur J Med Chem. 2012 Jun;52:304-12. doi: 10.1016/j.ejmech.2012.03.039. Epub 2012 Mar 29. Eur J Med Chem. 2012. PMID: 22483633
Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones.
da Silva Júnior EN, de Souza MC, Fernandes MC, Menna-Barreto RF, Pinto Mdo C, de Assis Lopes F, de Simone CA, Andrade CK, Pinto AV, Ferreira VF, de Castro SL. da Silva Júnior EN, et al. Among authors: de castro sl, de simone ca, de assis lopes f, de souza mc. Bioorg Med Chem. 2008 May 1;16(9):5030-8. doi: 10.1016/j.bmc.2008.03.032. Epub 2008 Mar 16. Bioorg Med Chem. 2008. PMID: 18378461
80 results