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Page 1
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F. Guimarães DSM, et al. Among authors: de pilla varotti f. Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22. Eur J Pharm Sci. 2019. PMID: 31344442
Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin.
Andrade AA, de Pilla Varotti F, de Freitas IO, de Souza MV, Vasconcelos TR, Boechat N, Krettli AU. Andrade AA, et al. Among authors: de freitas io, de pilla varotti f, de souza mv. Eur J Pharmacol. 2007 Mar 8;558(1-3):194-8. doi: 10.1016/j.ejphar.2006.11.061. Epub 2006 Dec 12. Eur J Pharmacol. 2007. PMID: 17214980
Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate.
de Pilla Varotti F, Botelho AC, Andrade AA, de Paula RC, Fagundes EM, Valverde A, Mayer LM, Mendonça JS, de Souza MV, Boechat N, Krettli AU. de Pilla Varotti F, et al. Among authors: de paula rc, de souza mv. Antimicrob Agents Chemother. 2008 Nov;52(11):3868-74. doi: 10.1128/AAC.00510-08. Epub 2008 Aug 18. Antimicrob Agents Chemother. 2008. PMID: 18710907 Free PMC article.
Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.
de Oliveira ME, Cenzi G, Nunes RR, Andrighetti CR, de Sousa Valadão DM, Dos Reis C, Simões CM, Nunes RJ, Júnior MC, Taranto AG, Sanchez BA, Viana GH, de Pilla Varotti F. de Oliveira ME, et al. Among authors: de pilla varotti f, de sousa valadao dm. Molecules. 2013 Dec 10;18(12):15276-87. doi: 10.3390/molecules181215276. Molecules. 2013. PMID: 24335577 Free PMC article.
Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.
Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH. Gonçalves AM, et al. Among authors: de lima ab, de oliveira jt, de souza barbosa c, de pilla varotti f, de camargos lf. Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361. Mar Drugs. 2014. PMID: 25089949 Free PMC article.
Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.
Barbosa MCS, de Souza Barbosa C, de Oliveira JT, Moreira NCS, de Miranda Martins NR, Alves Gomes GK, Caldeira CA, Alves E Costa ML, Martins Guimarães DS, Guimarães L, Nascimento CS Jr, de Pilla Varotti F, Ribeiro Viana GH, Santos FVD. Barbosa MCS, et al. Among authors: de oliveira jt, de souza barbosa c, de pilla varotti f, de miranda martins nr. Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:31-39. doi: 10.1016/j.mrgentox.2017.11.006. Epub 2017 Nov 24. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29307373
Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog.
Barbosa CS, Guimarães DSM, Gonçalves AMMN, Barbosa MCDS, Alves E Costa ML, Nascimento Júnior CS, Guimarães L, Ribeiro-Viana RM, Dos Santos FV, Alves de Brito CF, de Pilla Varotti F, Ribeiro Viana GH. Barbosa CS, et al. Among authors: de pilla varotti f. ACS Omega. 2017 Nov 30;2(11):8264-8272. doi: 10.1021/acsomega.7b01302. Epub 2017 Nov 21. ACS Omega. 2017. PMID: 30023579 Free PMC article.
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization.
Marinho JA, Martins Guimarães DS, Glanzmann N, de Almeida Pimentel G, Karine da Costa Nunes I, Gualberto Pereira HM, Navarro M, de Pilla Varotti F, David da Silva A, Abramo C. Marinho JA, et al. Among authors: de pilla varotti f. Eur J Med Chem. 2021 Apr 5;215:113271. doi: 10.1016/j.ejmech.2021.113271. Epub 2021 Feb 8. Eur J Med Chem. 2021. PMID: 33596489
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil.
Alves UV, Jardim E Silva E, Dos Santos JG, Santos LO, Lanna E, de Souza Pinto AC, Luisa da Fonseca A, de Pilla Varotti F, Batista R. Alves UV, et al. Among authors: de pilla varotti f. Int J Parasitol Drugs Drug Resist. 2021 Dec;17:80-83. doi: 10.1016/j.ijpddr.2021.08.002. Epub 2021 Aug 11. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34418583 Free PMC article.
19 results