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Page 1
Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.
de Oliveira ME, Cenzi G, Nunes RR, Andrighetti CR, de Sousa Valadão DM, Dos Reis C, Simões CM, Nunes RJ, Júnior MC, Taranto AG, Sanchez BA, Viana GH, de Pilla Varotti F. de Oliveira ME, et al. Among authors: de pilla varotti f, de sousa valadao dm. Molecules. 2013 Dec 10;18(12):15276-87. doi: 10.3390/molecules181215276. Molecules. 2013. PMID: 24335577 Free PMC article.
Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.
Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH. Gonçalves AM, et al. Among authors: de lima ab, de oliveira jt, de souza barbosa c, de pilla varotti f, de camargos lf. Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361. Mar Drugs. 2014. PMID: 25089949 Free PMC article.
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F. Guimarães DSM, et al. Among authors: de pilla varotti f. Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22. Eur J Pharm Sci. 2019. PMID: 31344442
Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria.
Alves FM, Bellei JCB, Barbosa CS, Duarte CL, Fonseca ALD, Pinto ACS, Raimundo FO, Carpinter BA, Lemos ASO, Coimbra ES, Taranto AG, Rocha VN, de Pilla Varotti F, Ribeiro Viana GH, Scopel KKG. Alves FM, et al. Among authors: de pilla varotti f. Pathogens. 2022 Dec 13;11(12):1529. doi: 10.3390/pathogens11121529. Pathogens. 2022. PMID: 36558863 Free PMC article.
Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.
Barbosa MCS, de Souza Barbosa C, de Oliveira JT, Moreira NCS, de Miranda Martins NR, Alves Gomes GK, Caldeira CA, Alves E Costa ML, Martins Guimarães DS, Guimarães L, Nascimento CS Jr, de Pilla Varotti F, Ribeiro Viana GH, Santos FVD. Barbosa MCS, et al. Among authors: de oliveira jt, de souza barbosa c, de pilla varotti f, de miranda martins nr. Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:31-39. doi: 10.1016/j.mrgentox.2017.11.006. Epub 2017 Nov 24. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29307373
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization.
Marinho JA, Martins Guimarães DS, Glanzmann N, de Almeida Pimentel G, Karine da Costa Nunes I, Gualberto Pereira HM, Navarro M, de Pilla Varotti F, David da Silva A, Abramo C. Marinho JA, et al. Among authors: de pilla varotti f. Eur J Med Chem. 2021 Apr 5;215:113271. doi: 10.1016/j.ejmech.2021.113271. Epub 2021 Feb 8. Eur J Med Chem. 2021. PMID: 33596489
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil.
Alves UV, Jardim E Silva E, Dos Santos JG, Santos LO, Lanna E, de Souza Pinto AC, Luisa da Fonseca A, de Pilla Varotti F, Batista R. Alves UV, et al. Among authors: de pilla varotti f. Int J Parasitol Drugs Drug Resist. 2021 Dec;17:80-83. doi: 10.1016/j.ijpddr.2021.08.002. Epub 2021 Aug 11. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34418583 Free PMC article.
A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Bezerra Bellei JC, Glanzmann N, Carpinter BA, Renhe DC, Marques CB, Azevedo MR, Barreto LM, Rocha VN, Karine da Costa Nunes I, Gualberto Pereira HM, Coimbra ES, Ferraz Coelho EA, David da Silva A, de Pilla Varotti F, Gorza Scopel KK. Bezerra Bellei JC, et al. Among authors: de pilla varotti f. Chem Biol Interact. 2022 Mar 1;355:109848. doi: 10.1016/j.cbi.2022.109848. Epub 2022 Feb 9. Chem Biol Interact. 2022. PMID: 35149084
19 results