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The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms.
Carvalho KM, Marinho Filho JD, de Melo TS, Araújo AJ, Quetz Jda S, da Cunha Mdo P, de Melo KM, da Silva AA, Tomé AR, Havt A, Fonseca SG, Brito GA, Chaves MH, Rao VS, Santos FA. Carvalho KM, et al. Among authors: de melo km. Evid Based Complement Alternat Med. 2015;2015:106157. doi: 10.1155/2015/106157. Epub 2015 Jan 29. Evid Based Complement Alternat Med. 2015. PMID: 25709707 Free PMC article.
Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses.
Carvalho KM, de Melo TS, de Melo KM, Quinderé AL, de Oliveira FT, Viana AF, Nunes PI, Quetz JD, Viana DA, da Silva AA, Havt A, Fonseca SG, Chaves MH, Rao VS, Santos FA. Carvalho KM, et al. Among authors: de melo km. Planta Med. 2017 Feb;83(3-04):285-291. doi: 10.1055/s-0042-114222. Epub 2016 Aug 15. Planta Med. 2017. PMID: 27525508
α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells.
de Melo KM, de Oliveira FTB, Costa Silva RA, Gomes Quinderé AL, Marinho Filho JDB, Araújo AJ, Barros Pereira ED, Carvalho AA, Chaves MH, Rao VS, Santos FA. de Melo KM, et al. Biomed Pharmacother. 2019 Jan;109:1860-1866. doi: 10.1016/j.biopha.2018.11.027. Epub 2018 Nov 26. Biomed Pharmacother. 2019. PMID: 30551441 Free article.
Health-Related Quality of Life and Health Resource Utilization in Patients with Primary Immunodeficiency Disease Prior to and Following 12 Months of Immunoglobulin G Treatment.
Routes J, Costa-Carvalho BT, Grimbacher B, Paris K, Ochs HD, Filipovich A, Hintermeyer M, de Melo KM, Workman S, Ito D, Ye X, Bonnet P, Li-McLeod J. Routes J, et al. Among authors: de melo km. J Clin Immunol. 2016 Jul;36(5):450-61. doi: 10.1007/s10875-016-0279-0. Epub 2016 Apr 18. J Clin Immunol. 2016. PMID: 27091140 Free PMC article.