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Novel tacrine derivatives that block neuronal calcium channels.
de los Ríos C, Marco JL, Carreiras MD, Chinchón PM, García AG, Villarroya M. de los Ríos C, et al. Bioorg Med Chem. 2002 Jun;10(6):2077-88. doi: 10.1016/s0968-0896(01)00378-9. Bioorg Med Chem. 2002. PMID: 11937366
Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.
Marco JL, de los Ríos C, García AG, Villarroya M, Carreiras MC, Martins C, Eleutério A, Morreale A, Orozco M, Luque FJ. Marco JL, et al. Among authors: de los rios c. Bioorg Med Chem. 2004 May 1;12(9):2199-218. doi: 10.1016/j.bmc.2004.02.017. Bioorg Med Chem. 2004. PMID: 15080920
ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.
Orozco C, de Los Rios C, Arias E, León R, García AG, Marco JL, Villarroya M, López MG. Orozco C, et al. Among authors: de los rios c. J Pharmacol Exp Ther. 2004 Sep;310(3):987-94. doi: 10.1124/jpet.104.068189. Epub 2004 Apr 26. J Pharmacol Exp Ther. 2004. PMID: 15111641
New multipotent tetracyclic tacrines with neuroprotective activity.
Marco-Contelles J, León R, de los Ríos C, García AG, López MG, Villarroya M. Marco-Contelles J, et al. Among authors: de los rios c. Bioorg Med Chem. 2006 Dec 15;14(24):8176-85. doi: 10.1016/j.bmc.2006.09.025. Epub 2006 Sep 26. Bioorg Med Chem. 2006. PMID: 17005406
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J. Samadi A, et al. Among authors: de los rios c. Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26. Bioorg Med Chem. 2011. PMID: 21163662
85 results