de Lange ECM - Search Results

1

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC. de Lange ECM, et al. Among authors: de witte wea. Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Expert Opin Drug Discov. 2017. PMID: 28933618 Review.

2

Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling.

de Lange EC, Ravenstijn PG, Groenendaal D, van Steeg TJ. de Lange EC, et al. AAPS J. 2005 Oct 7;7(3):E532-43. doi: 10.1208/aapsj070354. AAPS J. 2005. PMID: 16353931 Free PMC article. Review.

3

Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis.

Danhof M, de Jongh J, De Lange EC, Della Pasqua O, Ploeger BA, Voskuyl RA. Danhof M, et al. Annu Rev Pharmacol Toxicol. 2007;47:357-400. doi: 10.1146/annurev.pharmtox.47.120505.105154. Annu Rev Pharmacol Toxicol. 2007. PMID: 17067280 Review.

4

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

Danhof M, de Lange EC, Della Pasqua OE, Ploeger BA, Voskuyl RA. Danhof M, et al. Trends Pharmacol Sci. 2008 Apr;29(4):186-91. doi: 10.1016/j.tips.2008.01.007. Epub 2008 Mar 18. Trends Pharmacol Sci. 2008. PMID: 18353445 Review.

5

Utility of CSF in translational neuroscience.

de Lange EC. de Lange EC. J Pharmacokinet Pharmacodyn. 2013 Jun;40(3):315-26. doi: 10.1007/s10928-013-9301-9. Epub 2013 Feb 12. J Pharmacokinet Pharmacodyn. 2013. PMID: 23400635 Free PMC article. Review.

6

Prediction of methotrexate CNS distribution in different species - influence of disease conditions.

Westerhout J, van den Berg DJ, Hartman R, Danhof M, de Lange EC. Westerhout J, et al. Eur J Pharm Sci. 2014 Jun 16;57:11-24. doi: 10.1016/j.ejps.2013.12.020. Epub 2014 Jan 22. Eur J Pharm Sci. 2014. PMID: 24462766 Free article.

7

Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.

de Lange EC, Hammarlund-Udenaes M. de Lange EC, et al. Clin Pharmacol Ther. 2015 Apr;97(4):380-94. doi: 10.1002/cpt.76. Epub 2015 Feb 20. Clin Pharmacol Ther. 2015. PMID: 25670219 Review.

8

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC. de Witte WE, et al. Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Expert Opin Drug Discov. 2016. PMID: 26484747 Review.

9

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Among authors: de lange ecm. Trends Pharmacol Sci. 2016 Oct;37(10):831-842. doi: 10.1016/j.tips.2016.06.008. Epub 2016 Jul 6. Trends Pharmacol Sci. 2016. PMID: 27394919 Review.

10

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.

Yamamoto Y, Välitalo PA, van den Berg DJ, Hartman R, van den Brink W, Wong YC, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Bakshi S, Aranzana-Climent V, Marchand S, Dahyot-Fizelier C, Couet W, Danhof M, van Hasselt JG, de Lange EC. Yamamoto Y, et al. Pharm Res. 2017 Feb;34(2):333-351. doi: 10.1007/s11095-016-2065-3. Epub 2016 Nov 18. Pharm Res. 2017. PMID: 27864744 Free PMC article.

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