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Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.
Khandazhinskaya AL, Matyugina ES, Solyev PN, Wilkinson M, Buckheit KW, Buckheit RW Jr, Chernousova LN, Smirnova TG, Andreevskaya SN, Alzahrani KJ, Natto MJ, Kochetkov SN, de Koning HP, Seley-Radtke KL. Khandazhinskaya AL, et al. Among authors: de koning hp. Molecules. 2019 Sep 21;24(19):3433. doi: 10.3390/molecules24193433. Molecules. 2019. PMID: 31546633 Free PMC article.
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP. Munday JC, et al. Among authors: de koning hp. J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13. J Antimicrob Chemother. 2014. PMID: 24235095 Free PMC article.
In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.
Acosta-Reyes FJ, Dardonville C, de Koning HP, Natto M, Subirana JA, Campos JL. Acosta-Reyes FJ, et al. Among authors: de koning hp. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1614-21. doi: 10.1107/S139900471400697X. Epub 2014 May 24. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914972 Free PMC article.
Design and synthesis of a series of truncated neplanocin fleximers.
Zimmermann SC, O'Neill E, Ebiloma GU, Wallace LJ, De Koning HP, Seley-Radtke KL. Zimmermann SC, et al. Among authors: de koning hp. Molecules. 2014 Dec 16;19(12):21200-14. doi: 10.3390/molecules191221200. Molecules. 2014. PMID: 25521119 Free PMC article.
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP. Munday JC, et al. Among authors: de koning hp. Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21. Mol Microbiol. 2015. PMID: 25708978 Free PMC article.
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.
Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. Alzahrani KJH, et al. Among authors: de koning hp. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28453984 Free PMC article.
181 results