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In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.
Acosta-Reyes FJ, Dardonville C, de Koning HP, Natto M, Subirana JA, Campos JL. Acosta-Reyes FJ, et al. Among authors: de koning hp. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1614-21. doi: 10.1107/S139900471400697X. Epub 2014 May 24. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914972 Free PMC article.
A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines.
Ríos Martínez CH, Miller F, Ganeshamoorthy K, Glacial F, Kaiser M, de Koning HP, Eze AA, Lagartera L, Herraiz T, Dardonville C. Ríos Martínez CH, et al. Among authors: de koning hp. Antimicrob Agents Chemother. 2015 Feb;59(2):890-904. doi: 10.1128/AAC.03958-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421467 Free PMC article.
Design and synthesis of a series of truncated neplanocin fleximers.
Zimmermann SC, O'Neill E, Ebiloma GU, Wallace LJ, De Koning HP, Seley-Radtke KL. Zimmermann SC, et al. Among authors: de koning hp. Molecules. 2014 Dec 16;19(12):21200-14. doi: 10.3390/molecules191221200. Molecules. 2014. PMID: 25521119 Free PMC article.
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.
Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP. Rodenko B, et al. Among authors: de koning hp. Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17. Antimicrob Agents Chemother. 2015. PMID: 26282430 Free PMC article.
181 results