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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape.
de Jong MME, Kellermayer Z, Papazian N, Tahri S, Hofste Op Bruinink D, Hoogenboezem R, Sanders MA, van de Woestijne PC, Bos PK, Khandanpour C, Vermeulen J, Moreau P, van Duin M, Broijl A, Sonneveld P, Cupedo T. de Jong MME, et al. Nat Immunol. 2021 Jun;22(6):769-780. doi: 10.1038/s41590-021-00931-3. Epub 2021 May 20. Nat Immunol. 2021. PMID: 34017122 Clinical Trial.
A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML.
Chen L, Pronk E, van Dijk C, Bian Y, Feyen J, van Tienhoven T, Yildirim M, Pisterzi P, de Jong MME, Bastidas A, Hoogenboezem RM, Wevers C, Bindels EM, Löwenberg B, Cupedo T, Sanders MA, Raaijmakers MHGP. Chen L, et al. Among authors: de jong mme. Blood Cancer Discov. 2023 Sep 1;4(5):394-417. doi: 10.1158/2643-3230.BCD-23-0043. Blood Cancer Discov. 2023. PMID: 37470778 Free PMC article.
Bone marrow inflammation in haematological malignancies.
de Jong MME, Chen L, Raaijmakers MHGP, Cupedo T. de Jong MME, et al. Nat Rev Immunol. 2024 Mar 15. doi: 10.1038/s41577-024-01003-x. Online ahead of print. Nat Rev Immunol. 2024. PMID: 38491073 Review.
An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma.
de Jong MME, Fokkema C, Papazian N, Czeti Á, Appelman MK, Vermeulen M, van Heusden T, Hoogenboezem RM, van Beek G, Tahri S, Sanders MA, van de Woestijne PC, Gay F, Moreau P, Büttner-Herold M, Bruns H, van Duin M, Broijl A, Sonneveld P, Cupedo T. de Jong MME, et al. Nat Immunol. 2024 May;25(5):820-833. doi: 10.1038/s41590-024-01808-x. Epub 2024 Apr 10. Nat Immunol. 2024. PMID: 38600356