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Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib.
Steeghs N, Mathijssen RH, Wessels JA, de Graan AJ, van der Straaten T, Mariani M, Laffranchi B, Comis S, de Jonge MJ, Gelderblom H, Guchelaar HJ. Steeghs N, et al. Among authors: de graan aj, de jonge mj. Invest New Drugs. 2011 Oct;29(5):953-62. doi: 10.1007/s10637-010-9405-7. Epub 2010 Feb 25. Invest New Drugs. 2011. PMID: 20182906 Free PMC article. Clinical Trial.
Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer.
Gao B, Lu Y, Nieuweboer AJM, Xu H, Beesley J, Boere I, de Graan AM, de Bruijn P, Gurney H, J Kennedy C, Chiew YE, Johnatty SE, Beale P, Harrison M, Luccarini C, Conroy D, Mathijssen RHJ, R Harnett P, Balleine RL, Chenevix-Trench G, Macgregor S, de Fazio A. Gao B, et al. Sci Rep. 2018 Jan 24;8(1):1508. doi: 10.1038/s41598-018-19590-w. Sci Rep. 2018. PMID: 29367611 Free PMC article.
Effects of Budesonide on Cabazitaxel Pharmacokinetics and Cabazitaxel-Induced Diarrhea: A Randomized, Open-Label Multicenter Phase II Study.
Nieuweboer AJ, de Graan AM, Hamberg P, Bins S, van Soest RJ, van Alphen RJ, Bergman AM, Beeker A, van Halteren H, Ten Tije AJ, Zuetenhorst H, van der Meer N, Chitu D, de Wit R, Mathijssen RH; Dutch Uro-Oncology Studygroup (DUOS). Nieuweboer AJ, et al. Clin Cancer Res. 2017 Apr 1;23(7):1679-1683. doi: 10.1158/1078-0432.CCR-16-2110. Epub 2016 Oct 4. Clin Cancer Res. 2017. PMID: 27702823 Clinical Trial.
Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics.
Nieuweboer AJ, Smid M, de Graan AM, Elbouazzaoui S, de Bruijn P, Eskens FA, Hamberg P, Martens JW, Sparreboom A, de Wit R, van Schaik RH, Mathijssen RH. Nieuweboer AJ, et al. Pharmacogenomics J. 2016 Nov;16(6):519-524. doi: 10.1038/tpj.2015.66. Epub 2015 Sep 8. Pharmacogenomics J. 2016. PMID: 26345519
Predicting paclitaxel-induced neutropenia using the DMET platform.
Nieuweboer AJ, Smid M, de Graan AJ, Elbouazzaoui S, de Bruijn P, Martens JW, Mathijssen RH, van Schaik RH. Nieuweboer AJ, et al. Among authors: de graan aj. Pharmacogenomics. 2015;16(11):1231-41. doi: 10.2217/pgs.15.68. Epub 2015 Aug 12. Pharmacogenomics. 2015. PMID: 26265135
Inter-patient variability in docetaxel pharmacokinetics: A review.
Nieuweboer AJ, de Morrée ES, de Graan AJ, Sparreboom A, de Wit R, Mathijssen RH. Nieuweboer AJ, et al. Among authors: de graan aj. Cancer Treat Rev. 2015 Jul;41(7):605-13. doi: 10.1016/j.ctrv.2015.04.012. Epub 2015 May 7. Cancer Treat Rev. 2015. PMID: 25980322 Review.
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