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Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation.
Lkhagvadorj K, Zeng Z, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Plösch T, Hylkema MN. Lkhagvadorj K, et al. Among authors: de graaf iam. Int J Mol Sci. 2020 Dec 26;22(1):164. doi: 10.3390/ijms22010164. Int J Mol Sci. 2020. PMID: 33375250 Free PMC article.
Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring.
Lkhagvadorj K, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Plösch T, Hylkema MN. Lkhagvadorj K, et al. Among authors: de graaf iam. Epigenetics. 2020 Dec;15(12):1370-1385. doi: 10.1080/15592294.2020.1782655. Epub 2020 Jun 23. Epigenetics. 2020. PMID: 32573327 Free PMC article.
Rat precision-cut liver slices predict drug-induced cholestatic injury.
Starokozhko V, Greupink R, van de Broek P, Soliman N, Ghimire S, de Graaf IAM, Groothuis GMM. Starokozhko V, et al. Among authors: de graaf iam. Arch Toxicol. 2017 Oct;91(10):3403-3413. doi: 10.1007/s00204-017-1960-7. Epub 2017 Apr 8. Arch Toxicol. 2017. PMID: 28391356 Free PMC article.
58 results