de Graaf C - Search Results

1

A gold coordination compound as a chemical probe to unravel aquaporin-7 function.

Madeira A, de Almeida A, de Graaf C, Camps M, Zorzano A, Moura TF, Casini A, Soveral G. Madeira A, et al. Among authors: de almeida a, de graaf c. Chembiochem. 2014 Jul 7;15(10):1487-94. doi: 10.1002/cbic.201402103. Epub 2014 May 28. Chembiochem. 2014. PMID: 24891084

2

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.

Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M. Richter L, et al. Among authors: de esch ij, de graaf c. Nat Chem Biol. 2012 Mar 25;8(5):455-64. doi: 10.1038/nchembio.917. Nat Chem Biol. 2012. PMID: 22446838 Free PMC article.

3

The role and application of in silico docking in chemical genomics research.

Jongejan A, de Graaf C, Vermeulen NP, Leurs R, de Esch IJ. Jongejan A, et al. Among authors: de esch ij, de graaf c. Methods Mol Biol. 2005;310:63-91. doi: 10.1007/978-1-59259-948-6_5. Methods Mol Biol. 2005. PMID: 16350947

4

Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor.

Istyastono EP, de Graaf C, de Esch IJ, Leurs R. Istyastono EP, et al. Among authors: de esch ij, de graaf c. Curr Top Med Chem. 2011;11(6):661-79. doi: 10.2174/1568026611109060661. Curr Top Med Chem. 2011. PMID: 21261593 Review.

5

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

Akdemir A, Rucktooa P, Jongejan A, Elk Rv, Bertrand S, Sixma TK, Bertrand D, Smit AB, Leurs R, de Graaf C, de Esch IJ. Akdemir A, et al. Among authors: de esch ij, de graaf c. Bioorg Med Chem. 2011 Oct 15;19(20):6107-19. doi: 10.1016/j.bmc.2011.08.028. Epub 2011 Aug 27. Bioorg Med Chem. 2011. PMID: 21920761

6

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor.

de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R. de Graaf C, et al. Among authors: de esch ij. J Med Chem. 2011 Dec 8;54(23):8195-206. doi: 10.1021/jm2011589. Epub 2011 Nov 7. J Med Chem. 2011. PMID: 22007643 Free PMC article.

7

From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands.

Kooistra AJ, Roumen L, Leurs R, de Esch IJ, de Graaf C. Kooistra AJ, et al. Among authors: de esch ij, de graaf c. Methods Enzymol. 2013;522:279-336. doi: 10.1016/B978-0-12-407865-9.00015-7. Methods Enzymol. 2013. PMID: 23374191 Review.

8

Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.

Engelhardt H, Schultes S, de Graaf C, Nijmeijer S, Vischer HF, Zuiderveld OP, Dobler J, Stachurski K, Mayer M, Arnhof H, Scharn D, Haaksma EE, de Esch IJ, Leurs R. Engelhardt H, et al. Among authors: de esch ij, de graaf c. J Med Chem. 2013 Jun 13;56(11):4264-76. doi: 10.1021/jm301886t. Epub 2013 May 28. J Med Chem. 2013. PMID: 23668417

9

KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

van Linden OP, Kooistra AJ, Leurs R, de Esch IJ, de Graaf C. van Linden OP, et al. Among authors: de esch ij, de graaf c. J Med Chem. 2014 Jan 23;57(2):249-77. doi: 10.1021/jm400378w. Epub 2013 Sep 20. J Med Chem. 2014. PMID: 23941661

10

From three-dimensional GPCR structure to rational ligand discovery.

Kooistra AJ, Leurs R, de Esch IJ, de Graaf C. Kooistra AJ, et al. Among authors: de esch ij, de graaf c. Adv Exp Med Biol. 2014;796:129-57. doi: 10.1007/978-94-007-7423-0_7. Adv Exp Med Biol. 2014. PMID: 24158804 Review.

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