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Structural basis for elastolytic substrate specificity in rodent alpha-chymases.
Kervinen J, Abad M, Crysler C, Kolpak M, Mahan AD, Masucci JA, Bayoumy S, Cummings MD, Yao X, Olson M, de Garavilla L, Kuo L, Deckman I, Spurlino J. Kervinen J, et al. Among authors: de garavilla l. J Biol Chem. 2008 Jan 4;283(1):427-436. doi: 10.1074/jbc.M707157200. Epub 2007 Oct 31. J Biol Chem. 2008. PMID: 17981788 Free article.
Cleaved SLPI, a novel biomarker of chymase activity.
Belkowski SM, Masucci J, Mahan A, Kervinen J, Olson M, de Garavilla L, D'Andrea MR. Belkowski SM, et al. Among authors: de garavilla l. Biol Chem. 2008 Sep;389(9):1219-24. doi: 10.1515/BC.2008.138. Biol Chem. 2008. PMID: 18713008
Potency variation of small-molecule chymase inhibitors across species.
Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Kervinen J, et al. Among authors: de garavilla l. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. doi: 10.1016/j.bcp.2010.06.014. Epub 2010 Jun 23. Biochem Pharmacol. 2010. PMID: 20599788
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE. Costanzo MJ, et al. Among authors: de garavilla l. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21. doi: 10.1016/j.bmcl.2008.01.093. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18272363
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
de Garavilla L, Greco MN, Sukumar N, Chen ZW, Pineda AO, Mathews FS, Di Cera E, Giardino EC, Wells GI, Haertlein BJ, Kauffman JA, Corcoran TW, Derian CK, Eckardt AJ, Damiano BP, Andrade-Gordon P, Maryanoff BE. de Garavilla L, et al. J Biol Chem. 2005 May 6;280(18):18001-7. doi: 10.1074/jbc.M501302200. Epub 2005 Feb 28. J Biol Chem. 2005. PMID: 15741158 Free article.
58 results