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Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis.
Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. Piplani H, et al. Among authors: de freitas germano j. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165530. doi: 10.1016/j.bbadis.2019.08.006. Epub 2019 Aug 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31398467 Free article.
At the heart of mitochondrial quality control: many roads to the top.
Gottlieb RA, Piplani H, Sin J, Sawaged S, Hamid SM, Taylor DJ, de Freitas Germano J. Gottlieb RA, et al. Among authors: de freitas germano j. Cell Mol Life Sci. 2021 Apr;78(8):3791-3801. doi: 10.1007/s00018-021-03772-3. Epub 2021 Feb 5. Cell Mol Life Sci. 2021. PMID: 33544154 Free PMC article. Review.
Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis.
Rentsendorj A, Raedschelders K, Fuchs DT, Sheyn J, Vaibhav V, Porritt RA, Shi H, Dagvadorj J, de Freitas Germano J, Koronyo Y, Arditi M, Black KL, Gaire BP, Van Eyk JE, Koronyo-Hamaoui M. Rentsendorj A, et al. Among authors: de freitas germano j. Front Immunol. 2023 May 30;14:1155935. doi: 10.3389/fimmu.2023.1155935. eCollection 2023. Front Immunol. 2023. PMID: 37325640 Free PMC article.
Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model.
Leite G, de Freitas Germano J, Morales W, Weitsman S, Barlow GM, Parodi G, Pimentel ML, Villanueva-Millan MJ, Sanchez M, Ayyad S, Rezaie A, Mathur R, Pimentel M. Leite G, et al. Among authors: de freitas germano j. Gut Microbes. 2024 Jan-Dec;16(1):2293170. doi: 10.1080/19490976.2023.2293170. Epub 2023 Dec 18. Gut Microbes. 2024. PMID: 38108386 Free PMC article.