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Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM. Khang M, et al. Among authors: de feyter hm. Sci Transl Med. 2023 Nov;15(720):eadi1617. doi: 10.1126/scitranslmed.adi1617. Epub 2023 Nov 1. Sci Transl Med. 2023. PMID: 37910601 Free PMC article.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sulkowski PL, et al. Among authors: de feyter hm, de graaf ra. Sci Transl Med. 2017 Feb 1;9(375):eaal2463. doi: 10.1126/scitranslmed.aal2463. Sci Transl Med. 2017. PMID: 28148839 Free PMC article.
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates.
Chen B, Ojha DP, Toyonaga T, Tong J, Pracitto R, Thomas MA, Liu M, Kapinos M, Zhang L, Zheng MQ, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson RE, Huang Y, Cai Z. Chen B, et al. Eur J Nucl Med Mol Imaging. 2023 Jun;50(7):2081-2099. doi: 10.1007/s00259-023-06162-y. Epub 2023 Feb 28. Eur J Nucl Med Mol Imaging. 2023. PMID: 36849748
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. Martirosian V, et al. Cell Rep. 2021 Jun 29;35(13):109302. doi: 10.1016/j.celrep.2021.109302. Cell Rep. 2021. PMID: 34192534 Free PMC article.
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo.
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. De Feyter HM, et al. Among authors: de graaf ra. Sci Adv. 2018 Aug 22;4(8):eaat7314. doi: 10.1126/sciadv.aat7314. eCollection 2018 Aug. Sci Adv. 2018. PMID: 30140744 Free PMC article.
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status - A pilot study combining PET and deuterium metabolic imaging.
Meerwaldt AE, Straathof M, Oosterveld W, van Heijningen CL, van Leent MM, Toner YC, Munitz J, Teunissen AJ, Daemen CC, van der Toorn A, van Vliet G, van Tilborg GA, De Feyter HM, de Graaf RA, Hol EM, Mulder WJ, Dijkhuizen RM. Meerwaldt AE, et al. Among authors: de feyter hm. J Cereb Blood Flow Metab. 2023 May;43(5):778-790. doi: 10.1177/0271678X221148970. Epub 2023 Jan 6. J Cereb Blood Flow Metab. 2023. PMID: 36606595 Free PMC article.
Short symmetric and highly selective asymmetric first and second order gradient modulated offset independent adiabaticity (GOIA) pulses for applications in clinical MRS and MRSI.
Kumaragamage C, Coppoli A, Brown PB, McIntyre S, Nixon TW, De Feyter HM, Mason GF, de Graaf RA. Kumaragamage C, et al. Among authors: de feyter hm. J Magn Reson. 2022 Aug;341:107247. doi: 10.1016/j.jmr.2022.107247. Epub 2022 Jun 3. J Magn Reson. 2022. PMID: 35691241 Free PMC article.
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