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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: de candia m. Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30. Eur J Med Chem. 2023. PMID: 37567058 Free article.
Novel factor Xa inhibitors: a patent review.
de Candia M, Lopopolo G, Altomare C. de Candia M, et al. Expert Opin Ther Pat. 2009 Nov;19(11):1535-80. doi: 10.1517/13543770903270532. Expert Opin Ther Pat. 2009. PMID: 19743898 Review.
Protein crystallography and fragment-based drug design.
Caliandro R, Belviso DB, Aresta BM, de Candia M, Altomare CD. Caliandro R, et al. Among authors: de candia m. Future Med Chem. 2013 Jun;5(10):1121-40. doi: 10.4155/fmc.13.84. Future Med Chem. 2013. PMID: 23795969 Review.
How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
Belviso BD, Caliandro R, de Candia M, Zaetta G, Lopopolo G, Incampo F, Colucci M, Altomare CD. Belviso BD, et al. Among authors: de candia m. J Med Chem. 2014 Oct 23;57(20):8563-75. doi: 10.1021/jm5010754. Epub 2014 Oct 14. J Med Chem. 2014. PMID: 25268757
88 results