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Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.
Duregon E, Fernandez ME, Martinez Romero J, Di Germanio C, Cabassa M, Voloshchuk R, Ehrlich-Mora MR, Moats JM, Wong S, Bosompra O, Rudderow A, Morrell CH, Camandola S, Price NL, Aon MA, Bernier M, de Cabo R. Duregon E, et al. Among authors: de cabo r. Cell Metab. 2023 Jul 11;35(7):1179-1194.e5. doi: 10.1016/j.cmet.2023.05.003. Cell Metab. 2023. PMID: 37437544
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.
Winicki NM, Nanavati AP, Morrell CH, Moen JM, Axsom JE, Krawczyk M, Petrashevskaya NN, Beyman MG, Ramirez C, Alfaras I, Mitchell SJ, Juhaszova M, Riordon DR, Wang M, Zhang J, Cerami A, Brines M, Sollott SJ, de Cabo R, Lakatta EG. Winicki NM, et al. Among authors: de cabo r. Front Cardiovasc Med. 2023 Jan 18;9:1096887. doi: 10.3389/fcvm.2022.1096887. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36741836 Free PMC article.
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.
Occean JR, Yang N, Sun Y, Dawkins MS, Munk R, Belair C, Dar S, Anerillas C, Wang L, Shi C, Dunn C, Bernier M, Price NL, Kim JS, Cui CY, Fan J, Bhattacharyya M, De S, Maragkakis M, deCabo R, Sidoli S, Sen P. Occean JR, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.15.528714. doi: 10.1101/2023.02.15.528714. bioRxiv. 2023. PMID: 36824863 Free PMC article. Preprint.
Survey of organ-derived small extracellular vesicles and particles (sEVPs) to identify selective protein markers in mouse serum.
Abdelmohsen K, Herman AB, Carr AE, Henry-Smith CA, Rossi M, Meng Q, Yang JH, Tsitsipatis D, Bangura A, Munk R, Martindale JL, Nogueras-Ortiz CJ, Hao J, Gong Y, Liu Y, Cui CY, Hartnell LM, Price NL, Ferrucci L, Kapogiannis D, de Cabo R, Gorospe M. Abdelmohsen K, et al. Among authors: de cabo r. J Extracell Biol. 2023 Aug;2(8):e106. doi: 10.1002/jex2.106. Epub 2023 Aug 22. J Extracell Biol. 2023. PMID: 37744304 Free PMC article.
How is Big Data reshaping preclinical aging research?
Fernandez ME, Martinez-Romero J, Aon MA, Bernier M, Price NL, de Cabo R. Fernandez ME, et al. Among authors: de cabo r. Lab Anim (NY). 2023 Dec;52(12):289-314. doi: 10.1038/s41684-023-01286-y. Epub 2023 Nov 28. Lab Anim (NY). 2023. PMID: 38017182 Review.
Sex-specific metabolic adaptations in transgenic mice overexpressing cytochrome b5 reductase-3.
Sánchez-Mendoza LM, Pérez-Sánchez C, Rodríguez-López S, López-Pedrera C, Calvo-Rubio M, de Cabo R, Burón MI, González-Reyes JA, Villalba JM. Sánchez-Mendoza LM, et al. Among authors: de cabo r. Free Radic Biol Med. 2023 Oct;207:144-160. doi: 10.1016/j.freeradbiomed.2023.07.012. Epub 2023 Jul 16. Free Radic Biol Med. 2023. PMID: 37463636 Free article.
DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice.
Herman AB, Tsitsipatis D, Anerillas C, Mazan-Mamczarz K, Carr AE, Gregg JM, Wang M, Zhang J, Michel M, Henry-Smith CA, Harris SC, Munk R, Martindale JL, Piao Y, Fan J, Mattison JA, De S, Abdelmohsen K, Maul RW, Tanaka T, Moore AZ, DeMouth ME, Sidoli S, Ferrucci L, Liu Y, de Cabo R, Lakatta EG, Gorospe M. Herman AB, et al. Among authors: de cabo r, de s. J Clin Invest. 2023 Jun 15;133(12):e165933. doi: 10.1172/JCI165933. J Clin Invest. 2023. PMID: 37097759 Free PMC article.
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Among authors: de cabo r, de s. Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005. Epub 2023 Apr 27. Mol Cell. 2023. PMID: 37116496 Free article.
367 results