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Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
Vlaar APJ, Witzenrath M, van Paassen P, Heunks LMA, Mourvillier B, de Bruin S, Lim EHT, Brouwer MC, Tuinman PR, Saraiva JFK, Marx G, Lobo SM, Boldo R, Simon-Campos JA, Cornet AD, Grebenyuk A, Engelbrecht JM, Mukansi M, Jorens PG, Zerbib R, Rückinger S, Pilz K, Guo R, van de Beek D, Riedemann NC; PANAMO study group. Vlaar APJ, et al. Among authors: de bruin s. Lancet Respir Med. 2022 Dec;10(12):1137-1146. doi: 10.1016/S2213-2600(22)00297-1. Epub 2022 Sep 7. Lancet Respir Med. 2022. PMID: 36087611 Free PMC article. Clinical Trial.
Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.
Vlaar APJ, de Bruin S, Busch M, Timmermans SAMEG, van Zeggeren IE, Koning R, Ter Horst L, Bulle EB, van Baarle FEHP, van de Poll MCG, Kemper EM, van der Horst ICC, Schultz MJ, Horn J, Paulus F, Bos LD, Wiersinga WJ, Witzenrath M, Rueckinger S, Pilz K, Brouwer MC, Guo RF, Heunks L, van Paassen P, Riedemann NC, van de Beek D. Vlaar APJ, et al. Among authors: de bruin s. Lancet Rheumatol. 2020 Dec;2(12):e764-e773. doi: 10.1016/S2665-9913(20)30341-6. Epub 2020 Sep 28. Lancet Rheumatol. 2020. PMID: 33015643 Free PMC article.
Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study.
Botta M, Tsonas AM, Pillay J, Boers LS, Algera AG, Bos LDJ, Dongelmans DA, Hollmann MW, Horn J, Vlaar APJ, Schultz MJ, Neto AS, Paulus F; PRoVENT-COVID Collaborative Group. Botta M, et al. Lancet Respir Med. 2021 Feb;9(2):139-148. doi: 10.1016/S2213-2600(20)30459-8. Epub 2020 Oct 23. Lancet Respir Med. 2021. PMID: 33169671 Free PMC article.
Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19.
Saris A, Reijnders TDY, Nossent EJ, Schuurman AR, Verhoeff J, Asten SV, Bontkes H, Blok S, Duitman J, Bogaard HJ, Heunks L, Lutter R, van der Poll T, Garcia Vallejo JJ; ArtDECO consortium and the Amsterdam UMC COVID study group. Saris A, et al. Thorax. 2021 Oct;76(10):1010-1019. doi: 10.1136/thoraxjnl-2020-216256. Epub 2021 Apr 12. Thorax. 2021. PMID: 33846275 Free PMC article.
Complement inhibition in severe COVID-19 - Blocking C5a seems to be key.
Lim EHT, Vlaar APJ, de-Bruin S, Brouwer MC, van-de-Beek D. Lim EHT, et al. Among authors: de bruin s. EClinicalMedicine. 2021 Apr 24;35:100722. doi: 10.1016/j.eclinm.2021.100722. eCollection 2021 May. EClinicalMedicine. 2021. PMID: 33997737 Free PMC article. No abstract available.
Clinical features and prognostic factors in Covid-19: A prospective cohort study.
de Bruin S, Bos LD, van Roon MA, Tuip-de Boer AM, Schuurman AR, Koel-Simmelinck MJA, Bogaard HJ, Tuinman PR, van Agtmael MA, Hamann J, Teunissen CE, Wiersinga WJ, Koos Zwinderman AH, Brouwer MC, van de Beek D, Vlaar APJ; Amsterdam UMC COVID-19 Biobank Investigators. de Bruin S, et al. EBioMedicine. 2021 May;67:103378. doi: 10.1016/j.ebiom.2021.103378. Epub 2021 May 14. EBioMedicine. 2021. PMID: 34000622 Free PMC article.
Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts.
Bos LDJ, Sjoding M, Sinha P, Bhavani SV, Lyons PG, Bewley AF, Botta M, Tsonas AM, Serpa Neto A, Schultz MJ, Dickson RP, Paulus F; PRoVENT-COVID collaborative group. Bos LDJ, et al. Lancet Respir Med. 2021 Dec;9(12):1377-1386. doi: 10.1016/S2213-2600(21)00365-9. Epub 2021 Oct 13. Lancet Respir Med. 2021. PMID: 34653374 Free PMC article.
178 results