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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Demange P, Joly E, Marcoux J, Zanon PRA, Listunov D, Rullière P, Barthes C, Noirot C, Izquierdo JB, Rozié A, Pradines K, Hee R, de Brito MV, Marcellin M, Serre RF, Bouchez O, Burlet-Schiltz O, Oliveira MCF, Ballereau S, Bernardes-Génisson V, Maraval V, Calsou P, Hacker SM, Génisson Y, Chauvin R, Britton S. Demange P, et al. Among authors: de brito mv. Elife. 2022 May 10;11:e73913. doi: 10.7554/eLife.73913. Elife. 2022. PMID: 35535493 Free PMC article.
A plant proteinase inhibitor from Enterolobium contortisiliquum attenuates airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma.
Rodrigues APD, Bortolozzo ASS, Arantes-Costa FM, Saraiva-Romanholo BM, de Souza FCR, Brüggemann TR, Santana FPR, de Brito MV, Bonturi CR, Nunes NNDS, Prado CM, Leick EA, Oliva MLV, Martins MA, Righetti RF, Tibério IFLC. Rodrigues APD, et al. Among authors: de brito mv. Histol Histopathol. 2019 May;34(5):537-552. doi: 10.14670/HH-18-059. Epub 2018 Nov 8. Histol Histopathol. 2019. PMID: 30407608
The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice.
Bortolozzo ASS, Rodrigues APD, Arantes-Costa FM, Saraiva-Romanholo BM, de Souza FCR, Brüggemann TR, de Brito MV, Ferreira RDS, Correia MTDS, Paiva PMG, Prado CM, Leick EA, Oliva MLV, Martins MA, Ruiz-Schutz VC, Righetti RF, Tibério IFLC. Bortolozzo ASS, et al. Among authors: de brito mv. Biomed Res Int. 2018 Oct 1;2018:9274817. doi: 10.1155/2018/9274817. eCollection 2018. Biomed Res Int. 2018. PMID: 30364003 Free PMC article.
Annonalide and derivatives: Semisynthesis, cytotoxic activities and studies on interaction of annonalide with DNA.
Marques RA, Gomes AOCV, de Brito MV, Dos Santos ALP, da Silva GS, de Lima LB, Nunes FM, de Mattos MC, de Oliveira FCE, do Ó Pessoa C, de Moraes MO, de Fátima Â, Franco LL, Silva MM, Dantas MDA, Santos JCC, Figueiredo IM, da Silva-Júnior EF, de Aquino TM, de Araújo-Júnior JX, de Oliveira MCF, Leslie Gunatilaka AA. Marques RA, et al. Among authors: de brito mv. J Photochem Photobiol B. 2018 Feb;179:156-166. doi: 10.1016/j.jphotobiol.2018.01.016. Epub 2018 Feb 3. J Photochem Photobiol B. 2018. PMID: 29413989
Zoanthid mucus as new source of useful biologically active proteins.
Guarnieri MC, de Albuquerque Modesto JC, Pérez CD, Ottaiano TF, Ferreira RDS, Batista FP, de Brito MV, Campos IHMP, Oliva MLV. Guarnieri MC, et al. Among authors: de brito mv. Toxicon. 2018 Mar 1;143:96-107. doi: 10.1016/j.toxicon.2018.01.012. Epub 2018 Jan 31. Toxicon. 2018. PMID: 29360533
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