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Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution.
Castillo-Ecija H, Monterrubio C, Pascual-Pasto G, Gomez-Gonzalez S, Garcia-Dominguez DJ, Hontecillas-Prieto L, Resa-Pares C, Burgueño V, Paco S, Olaciregui NG, Vila-Ubach M, Restrepo-Perdomo C, Cuadrado-Vilanova M, Balaguer-Lluna L, Perez-Jaume S, Castañeda A, Santa-Maria V, Roldan M, Suñol M, de Alava E, Mora J, Lavarino C, Carcaboso AM. Castillo-Ecija H, et al. Among authors: de alava e. J Control Release. 2020 Aug 10;324:440-449. doi: 10.1016/j.jconrel.2020.05.032. Epub 2020 Jun 1. J Control Release. 2020. PMID: 32497782
Differential expression of genes mapping to recurrently abnormal chromosomal regions characterize neuroblastic tumours with distinct ploidy status.
Lavarino C, Garcia I, Mackintosh C, Cheung NK, Domenech G, Ríos J, Perez N, Rodríguez E, de Torres C, Gerald WL, Tuset E, Acosta S, Beleta H, de Alava E, Mora J. Lavarino C, et al. Among authors: de torres c, de alava e. BMC Med Genomics. 2008 Aug 13;1:36. doi: 10.1186/1755-8794-1-36. BMC Med Genomics. 2008. PMID: 18700951 Free PMC article.
The clinical relevance of molecular genetics in soft tissue sarcomas.
Ordóñez JL, Osuna D, García-Domínguez DJ, Amaral AT, Otero-Motta AP, Mackintosh C, Sevillano MV, Barbado MV, Hernández T, de Alava E. Ordóñez JL, et al. Among authors: de alava e. Adv Anat Pathol. 2010 May;17(3):162-81. doi: 10.1097/PAP.0b013e3181d98cbf. Adv Anat Pathol. 2010. PMID: 20418671 Review.
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Mackintosh C, Ordóñez JL, García-Domínguez DJ, Sevillano V, Llombart-Bosch A, Szuhai K, Scotlandi K, Alberghini M, Sciot R, Sinnaeve F, Hogendoorn PC, Picci P, Knuutila S, Dirksen U, Debiec-Rychter M, Schaefer KL, de Álava E. Mackintosh C, et al. Among authors: de alava e. Oncogene. 2012 Mar 8;31(10):1287-98. doi: 10.1038/onc.2011.317. Epub 2011 Aug 8. Oncogene. 2012. PMID: 21822310
The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis.
Casalà C, Gil-Guiñón E, Ordóñez JL, Miguel-Queralt S, Rodríguez E, Galván P, Lavarino C, Munell F, de Alava E, Mora J, de Torres C. Casalà C, et al. Among authors: de alava e, de torres c. Carcinogenesis. 2013 Feb;34(2):268-76. doi: 10.1093/carcin/bgs338. Epub 2012 Oct 29. Carcinogenesis. 2013. PMID: 23108190
EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1.
Sáinz-Jaspeado M, Huertas-Martinez J, Lagares-Tena L, Martin Liberal J, Mateo-Lozano S, de Alava E, de Torres C, Mora J, Del Muro XG, Tirado OM. Sáinz-Jaspeado M, et al. Among authors: de alava e, de torres c. PLoS One. 2013 Aug 12;8(8):e71449. doi: 10.1371/journal.pone.0071449. eCollection 2013. PLoS One. 2013. PMID: 23951165 Free PMC article.
Innovative therapies in Ewing Sarcoma.
Amaral AT, Ordóñez JL, Otero-Motta AP, García-Domínguez DJ, Sevillano MV, de Álava E. Amaral AT, et al. Among authors: de alava e. Adv Anat Pathol. 2014 Jan;21(1):44-62. doi: 10.1097/PAP.0000000000000003. Adv Anat Pathol. 2014. PMID: 24316910 Review.
Desmoplastic small round cell tumor 20 years after its discovery.
Mora J, Modak S, Cheung NK, Meyers P, de Alava E, Kushner B, Magnan H, Tirado OM, Laquaglia M, Ladanyi M, Rosai J. Mora J, et al. Among authors: de alava e. Future Oncol. 2015;11(7):1071-81. doi: 10.2217/fon.15.32. Future Oncol. 2015. PMID: 25804122
209 results