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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis.
Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L. Anastasia I, et al. Among authors: de aguiar vallim tq. Cell Rep. 2021 Mar 16;34(11):108873. doi: 10.1016/j.celrep.2021.108873. Cell Rep. 2021. PMID: 33730569 Free article.
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. Clifford BL, et al. Among authors: de aguiar vallim tq. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. Cell Metab. 2021. PMID: 34270928 Free PMC article.
ZFP36-mediated mRNA decay regulates metabolism.
Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ, Christofk HR. Cicchetto AC, et al. Among authors: de aguiar vallim tq. Cell Rep. 2023 May 30;42(5):112411. doi: 10.1016/j.celrep.2023.112411. Epub 2023 Apr 21. Cell Rep. 2023. PMID: 37086408 Free PMC article.
Pleiotropic roles of bile acids in metabolism.
de Aguiar Vallim TQ, Tarling EJ, Edwards PA. de Aguiar Vallim TQ, et al. Cell Metab. 2013 May 7;17(5):657-69. doi: 10.1016/j.cmet.2013.03.013. Epub 2013 Apr 18. Cell Metab. 2013. PMID: 23602448 Free PMC article. Review.
MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. de Aguiar Vallim TQ, et al. Cell Metab. 2015 Feb 3;21(2):298-311. doi: 10.1016/j.cmet.2015.01.007. Cell Metab. 2015. PMID: 25651182 Free PMC article.
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Xiao X, et al. Among authors: de aguiar vallim tq. Nat Metab. 2023 Jan;5(1):165-181. doi: 10.1038/s42255-022-00722-6. Epub 2023 Jan 16. Nat Metab. 2023. PMID: 36646756 Free PMC article.
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