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Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Bioorg Med Chem Lett. 2022 Jul 15;68:128764. doi: 10.1016/j.bmcl.2022.128764. Epub 2022 May 2.
Bioorg Med Chem Lett. 2022.
PMID: 35504513
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM.
Serafim RAM, et al. Among authors: da silva santiago a.
ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12.
ACS Med Chem Lett. 2019.
PMID: 31531195
Free PMC article.
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Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
M Serafim RA, da Silva Santiago A, Schwalm MP, Hu Z, Dos Reis CV, Takarada JE, Mezzomo P, Massirer KB, Kudolo M, Gerstenecker S, Chaikuad A, Zender L, Knapp S, Laufer S, Couñago RM, Gehringer M.
M Serafim RA, et al. Among authors: da silva santiago a.
J Med Chem. 2022 Feb 24;65(4):3173-3192. doi: 10.1021/acs.jmedchem.1c01165. Epub 2022 Feb 15.
J Med Chem. 2022.
PMID: 35167750
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Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5.
Hunashal Y, Kumar GS, Choy MS, D'Andréa ÉD, Da Silva Santiago A, Schoenle MV, Desbonnet C, Arthur M, Rice LB, Page R, Peti W.
Hunashal Y, et al. Among authors: da silva santiago a.
Nat Commun. 2023 Jul 17;14(1):4268. doi: 10.1038/s41467-023-39966-5.
Nat Commun. 2023.
PMID: 37460557
Free PMC article.
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Proteomic analysis during of spore germination of Moniliophthora perniciosa, the causal agent of witches' broom disease in cacao.
Mares JH, Gramacho KP, Santos EC, da Silva Santiago A, Santana JO, de Sousa AO, Alvim FC, Pirovani CP.
Mares JH, et al. Among authors: da silva santiago a.
BMC Microbiol. 2017 Aug 17;17(1):176. doi: 10.1186/s12866-017-1085-4.
BMC Microbiol. 2017.
PMID: 28818052
Free PMC article.
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Theobroma cacao cystatins impair Moniliophthora perniciosa mycelial growth and are involved in postponing cell death symptoms.
Pirovani CP, da Silva Santiago A, dos Santos LS, Micheli F, Margis R, da Silva Gesteira A, Alvim FC, Pereira GA, de Mattos Cascardo JC.
Pirovani CP, et al. Among authors: da silva santiago a.
Planta. 2010 Nov;232(6):1485-97. doi: 10.1007/s00425-010-1272-0. Epub 2010 Sep 22.
Planta. 2010.
PMID: 20859638
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