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Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines.
Costa MP, Feitosa ACS, Oliveira FCE, Cavalcanti BC, Dias GG, Caetano EWS, Sales FAM, Freire VN, Di Fiore S, Fischer R, Ladeira LO, da Silva Júnior EN, Pessoa C. Costa MP, et al. Among authors: da silva junior en. Medchemcomm. 2017 Sep 7;8(10):1993-2002. doi: 10.1039/c7md00196g. eCollection 2017 Oct 1. Medchemcomm. 2017. PMID: 30108718 Free PMC article.
Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.
Carneiro PF, Pinto Mdo C, Coelho TS, Cavalcanti BC, Pessoa C, de Simone CA, Nunes IK, de Oliveira NM, de Almeida RG, Pinto AV, de Moura KC, da Silva PA, da Silva Júnior EN. Carneiro PF, et al. Among authors: da silva pa, da silva junior en. Eur J Med Chem. 2011 Sep;46(9):4521-9. doi: 10.1016/j.ejmech.2011.07.026. Epub 2011 Jul 23. Eur J Med Chem. 2011. PMID: 21820768
Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts.
Cavalcanti BC, Barros FW, Cabral IO, Ferreira JR, Magalhães HI, Júnior HV, da Silva Júnior EN, de Abreu FC, Costa CO, Goulart MO, Moraes MO, Pessoa C. Cavalcanti BC, et al. Among authors: da silva junior en, junior hv. Chem Res Toxicol. 2011 Sep 19;24(9):1560-74. doi: 10.1021/tx200180y. Epub 2011 Aug 23. Chem Res Toxicol. 2011. PMID: 21830773
Growth inhibitory effects of 3'-nitro-3-phenylamino nor-beta-lapachone against HL-60: a redox-dependent mechanism.
Araújo AJ, de Souza AA, da Silva Júnior EN, Marinho-Filho JD, de Moura MA, Rocha DD, Vasconcellos MC, Costa CO, Pessoa C, de Moraes MO, Ferreira VF, de Abreu FC, Pinto AV, Montenegro RC, Costa-Lotufo LV, Goulart MO. Araújo AJ, et al. Among authors: da silva junior en. Toxicol In Vitro. 2012 Jun;26(4):585-94. doi: 10.1016/j.tiv.2012.02.003. Epub 2012 Feb 22. Toxicol In Vitro. 2012. PMID: 22386657 Free article.
Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
Diogo EB, Dias GG, Rodrigues BL, Guimarães TT, Valença WO, Camara CA, de Oliveira RN, da Silva MG, Ferreira VF, de Paiva YG, Goulart MO, Menna-Barreto RF, de Castro SL, da Silva Júnior EN. Diogo EB, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2013 Nov 1;21(21):6337-48. doi: 10.1016/j.bmc.2013.08.055. Epub 2013 Sep 6. Bioorg Med Chem. 2013. PMID: 24074878 Free article.
1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.
da Cruz EH, Hussene CM, Dias GG, Diogo EB, de Melo IM, Rodrigues BL, da Silva MG, Valença WO, Camara CA, de Oliveira RN, de Paiva YG, Goulart MO, Cavalcanti BC, Pessoa C, da Silva Júnior EN. da Cruz EH, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2014 Mar 1;22(5):1608-19. doi: 10.1016/j.bmc.2014.01.033. Epub 2014 Jan 31. Bioorg Med Chem. 2014. PMID: 24530030 Free article.
Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis.
Neto JB, da Silva CR, Neta MA, Campos RS, Siebra JT, Silva RA, Gaspar DM, Magalhães HI, de Moraes MO, Lobo MD, Grangeiro TB, Carvalho TS, Diogo EB, da Silva Júnior EN, Rodrigues FA, Cavalcanti BC, Júnior HV. Neto JB, et al. Among authors: da silva cr, silva ra, da silva junior en, junior hv. PLoS One. 2014 May 9;9(5):e93698. doi: 10.1371/journal.pone.0093698. eCollection 2014. PLoS One. 2014. PMID: 24817320 Free PMC article.
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
da Cruz EHG, Silvers MA, Jardim GAM, Resende JM, Cavalcanti BC, Bomfim IS, Pessoa C, de Simone CA, Botteselle GV, Braga AL, Nair DK, Namboothiri INN, Boothman DA, da Silva Júnior EN. da Cruz EHG, et al. Among authors: da silva junior en. Eur J Med Chem. 2016 Oct 21;122:1-16. doi: 10.1016/j.ejmech.2016.06.019. Epub 2016 Jun 14. Eur J Med Chem. 2016. PMID: 27341379 Free PMC article.
84 results