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Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.
Maltarollo VG, da Silva EB, Kronenberger T, Sena Andrade MM, de Lima Marques GV, Cândido Oliveira NJ, Santos LH, Oliveira Rezende Júnior C, Cassiano Martinho AC, Skinner D, Fajtová P, M Fernandes TH, Silveira Dos Santos ED, Rodrigues Gazolla PA, Martins de Souza AP, da Silva ML, Dos Santos FS, Lavorato SN, Oliveira Bretas AC, Carvalho DT, Franco LL, Luedtke S, Giardini MA, Poso A, Dias LC, Podust LM, Alves RJ, McKerrow J, Andrade SF, Teixeira RR, Siqueira-Neto JL, O'Donoghue A, de Oliveira RB, Ferreira RS. Maltarollo VG, et al. Among authors: da silva ml, da silva eb. Future Med Chem. 2023 Jun;15(11):959-985. doi: 10.4155/fmc-2023-0034. Epub 2023 Jul 12. Future Med Chem. 2023. PMID: 37435731
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
Cardoso MV, de Siqueira LR, da Silva EB, Costa LB, Hernandes MZ, Rabello MM, Ferreira RS, da Cruz LF, Moreira DR, Pereira VR, de Castro MC, Bernhardt PV, Leite AC. Cardoso MV, et al. Among authors: da silva eb, da cruz lf. Eur J Med Chem. 2014 Oct 30;86:48-59. doi: 10.1016/j.ejmech.2014.08.012. Epub 2014 Aug 6. Eur J Med Chem. 2014. PMID: 25147146
Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death.
da Silva EB, Oliveira E Silva DA, Oliveira AR, da Silva Mendes CH, Dos Santos TA, da Silva AC, de Castro MC, Ferreira RS, Moreira DR, Cardoso MV, de Simone CA, Pereira VR, Leite AC. da Silva EB, et al. Among authors: da silva ac, da silva mendes ch. Eur J Med Chem. 2017 Apr 21;130:39-50. doi: 10.1016/j.ejmech.2017.02.026. Epub 2017 Feb 16. Eur J Med Chem. 2017. PMID: 28242550
Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Pereira GAN, da Silva EB, Braga SFP, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FMR, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS. Pereira GAN, et al. Among authors: da silva eb. Eur J Med Chem. 2019 Oct 1;179:765-778. doi: 10.1016/j.ejmech.2019.06.062. Epub 2019 Jun 22. Eur J Med Chem. 2019. PMID: 31284086 Free PMC article.
In vitro results with minimal blood toxicity of a combretastatin A4 analogue.
Chagas C, Mansano JV, da Silva EB, Petri G, da Costa Aguiar Alves Reis B, Schumacher ML, Haddad PS, Pereira EC, Britos TN, Barreiro EJ, Lima LM, Ferreira FF, Fonseca FLA. Chagas C, et al. Among authors: da silva eb. Invest New Drugs. 2024 May 17. doi: 10.1007/s10637-024-01440-4. Online ahead of print. Invest New Drugs. 2024. PMID: 38758478
123 results