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Development of a liquid chromatography Q Exactive high resolution mass spectrometry method by the Box-Behnken design for the investigation of sibutramine urinary metabolites.
de Souza Anselmo C, Matias BF, Sardela VF, Ribeiro AF, da Costa Nunes IK, de Sousa VP, Pereira HMG. de Souza Anselmo C, et al. Among authors: da costa nunes ik. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121726. doi: 10.1016/j.jchromb.2019.121726. Epub 2019 Jul 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 31362180
Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents.
Zapata-Sudo G, da Costa Nunes IK, Araujo JS, da Silva JS, Trachez MM, da Silva TF, da Costa FP, Sudo RT, Barreiro EJ, Lima LM. Zapata-Sudo G, et al. Among authors: da costa nunes ik. Drug Des Devel Ther. 2016 Sep 9;10:2869-2879. doi: 10.2147/DDDT.S108327. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27672310 Free PMC article.
New phosphodiesterase-4 inhibitors present airways relaxant activity in a guinea pig acute asthma model.
Martins IRR, de Melo Medeiros M, Vasconcelos LHC, Silva MDCC, Queiroga FR, Cavalcante-Silva LHA, da Costa Nunes IK, Lima LM, da Silva PM, Silva BAD. Martins IRR, et al. Among authors: da costa nunes ik. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec 18. doi: 10.1007/s00210-023-02905-8. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 38108836