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Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF. Vicente Miranda H, et al. Among authors: zweckstetter m. Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056. Brain. 2017. PMID: 28398476
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.
Rasia RM, Bertoncini CW, Marsh D, Hoyer W, Cherny D, Zweckstetter M, Griesinger C, Jovin TM, Fernández CO. Rasia RM, et al. Among authors: zweckstetter m. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4294-9. doi: 10.1073/pnas.0407881102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767574 Free PMC article.
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
El-Turk F, Cascella M, Ouertatani-Sakouhi H, Narayanan RL, Leng L, Bucala R, Zweckstetter M, Rothlisberger U, Lashuel HA. El-Turk F, et al. Among authors: zweckstetter m. Biochemistry. 2008 Oct 7;47(40):10740-56. doi: 10.1021/bi800603x. Epub 2008 Sep 17. Biochemistry. 2008. PMID: 18795803 Free PMC article.
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.
Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M. Karpinar DP, et al. Among authors: zweckstetter m. EMBO J. 2009 Oct 21;28(20):3256-68. doi: 10.1038/emboj.2009.257. Epub 2009 Sep 10. EMBO J. 2009. PMID: 19745811 Free PMC article.
287 results