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Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium; Neurath MF, Wirtz S, Becker C. Erkert L, et al. Gut. 2024 Apr 29:gutjnl-2023-331622. doi: 10.1136/gutjnl-2023-331622. Online ahead of print. Gut. 2024. PMID: 38684238
Blocking GPR15 counteracts integrin-dependent T cell gut homing in vivo.
Schramm S, Liu LJ, Saad M, Dietz L, Dedden M, Müller TM, Atreya I, Voskens CJ, Atreya R, Neurath MF, Zundler S. Schramm S, et al. Among authors: zundler s. J Crohns Colitis. 2024 Jan 18:jjae012. doi: 10.1093/ecco-jcc/jjae012. Online ahead of print. J Crohns Colitis. 2024. PMID: 38243565
ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.
Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C; TRR241 IBDome Consortium; Zundler S, Becker C, Atreya R, Neurath MF, Atreya I. Schulz-Kuhnt A, et al. Among authors: zundler s. Gut. 2024 Mar 7;73(4):601-612. doi: 10.1136/gutjnl-2023-330543. Gut. 2024. PMID: 38176897
Long-term outcomes of cyclosporin induction and ustekinumab maintenance combination therapy in patients with steroid-refractory acute severe ulcerative colitis.
Vitali F, Rath T, Klenske E, Vögele AL, Ganzleben I, Zundler S, Strobel D, Geppert C, Hartmann A, Neurath MF, Atreya R. Vitali F, et al. Among authors: zundler s. Therap Adv Gastroenterol. 2023 Dec 30;17:17562848231218555. doi: 10.1177/17562848231218555. eCollection 2024. Therap Adv Gastroenterol. 2023. PMID: 38164363 Free PMC article.
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
Chiriac MT, Hracsko Z, Günther C, Gonzalez-Acera M, Atreya R, Stolzer I, Wittner L, Dressel A, Schickedanz L, Gamez-Belmonte R, Erkert L, Hundorfean G, Zundler S, Rath T, Vetrano S, Danese S, Sturm G, Trajanoski Z, Kühl AA, Siegmund B, Hartmann A, Wirtz S, Siebler J, Finotto S, Becker C, Neurath MF. Chiriac MT, et al. Among authors: zundler s. Gut. 2024 Jan 5;73(2):282-297. doi: 10.1136/gutjnl-2023-329628. Gut. 2024. PMID: 37884352 Free PMC article.
Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis.
Rath T, Atreya R, Bodenschatz J, Uter W, Geppert CI, Vitali F, Zundler S, Waldner MJ, Hartmann A, Neurath MF. Rath T, et al. Among authors: zundler s. Front Med (Lausanne). 2023 Oct 10;10:1221449. doi: 10.3389/fmed.2023.1221449. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37881628 Free PMC article.
NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases.
Weber S, Sitte S, Voegele AL, Sologub L, Wilfer A, Rath T, Nägel A, Zundler S, Franchi L, Opipari AW, Sonnewald S, Reid S, Hartmann A, Eichhorn P, Handtrack C, Weber K, Grützmann R, Neufert C, Schellerer VS, Naschberger E, Ekici AB, Büttner C, Neurath MF, Atreya R. Weber S, et al. Among authors: zundler s. J Crohns Colitis. 2024 Mar 1;18(3):446-461. doi: 10.1093/ecco-jcc/jjad164. J Crohns Colitis. 2024. PMID: 37748021
85 results