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Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
Sumner RP, Harrison L, Touizer E, Peacock TP, Spencer M, Zuliani-Alvarez L, Towers GJ. Sumner RP, et al. EMBO J. 2020 Oct 15;39(20):e103958. doi: 10.15252/embj.2019103958. Epub 2020 Aug 27. EMBO J. 2020. PMID: 32852081 Free PMC article.
Identifying a nuclear passport for HIV.
Zuliani-Alvarez L, Towers GJ. Zuliani-Alvarez L, et al. Elife. 2019 Mar 5;8:e45580. doi: 10.7554/eLife.45580. Elife. 2019. PMID: 30834893 Free PMC article.
Evolution of enhanced innate immune evasion by SARS-CoV-2.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. Thorne LG, et al. Nature. 2022 Feb;602(7897):487-495. doi: 10.1038/s41586-021-04352-y. Epub 2021 Dec 23. Nature. 2022. PMID: 34942634 Free PMC article.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, Fernandez de Orueta L, Torralba M, Fortun J, Vates R, Barberan J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijon P, Monereo A, Abad D, Zuñiga S, Sola I, Rodon J, Vergara-Alert J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Giron de Velasco P, Nieto A, Gomez J, Aviles P, Lubomirov R, Belgrano A, Sopesen B, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, McGovern BL, Rodriguez ML, Enjuanes L, Fernandez-Sousa JM, Krogan NJ, Jimeno JM, Garcia-Sastre A. Varona JF, et al. Life Sci Alliance. 2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200. Print 2022 Apr. Life Sci Alliance. 2022. PMID: 35012962 Free PMC article. Clinical Trial.
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. Thorne LG, et al. Among authors: zuliani alvarez l. Nature. 2022 Apr;604(7905):E14. doi: 10.1038/s41586-022-04653-w. Nature. 2022. PMID: 35332335 Free PMC article. No abstract available.
Evasion of cGAS and TRIM5 defines pandemic HIV.
Zuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ. Zuliani-Alvarez L, et al. Nat Microbiol. 2022 Nov;7(11):1762-1776. doi: 10.1038/s41564-022-01247-0. Epub 2022 Oct 26. Nat Microbiol. 2022. PMID: 36289397 Free PMC article.
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
Reuschl AK, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J, Fabius JM, Nguyen GT, Swaney DL, Rosales R, White KM, Avilés P, Kirby IT, Melnyk JE, Shi Y, Zhang Z, Shokat KM, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. Reuschl AK, et al. bioRxiv [Preprint]. 2021 Feb 4:2021.01.24.427991. doi: 10.1101/2021.01.24.427991. bioRxiv. 2021. PMID: 33501437 Free PMC article. Preprint.
28 results