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SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Mol Cancer Ther. 2019 Jun;18(6):1036-1044. doi: 10.1158/1535-7163.MCT-18-1206. Epub 2019 Apr 24.
Mol Cancer Ther. 2019.
PMID: 31018997
Free PMC article.
A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.
Joshi S, Singh AR, Zulcic M, Durden DL.
Joshi S, et al. Among authors: zulcic m.
Mol Cancer Res. 2014 Oct;12(10):1520-31. doi: 10.1158/1541-7786.MCR-13-0682. Epub 2014 Aug 7.
Mol Cancer Res. 2014.
PMID: 25103499
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Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression.
Joshi S, Liu KX, Zulcic M, Singh AR, Skola D, Glass CK, Sanders PD, Sharabi AB, Pham TV, Tamayo P, Shiang D, Dinh HQ, Hedrick CC, Morales GA, Garlich JR, Durden DL.
Joshi S, et al. Among authors: zulcic m.
Mol Cancer Ther. 2020 Mar;19(3):755-764. doi: 10.1158/1535-7163.MCT-19-0947. Epub 2020 Jan 23.
Mol Cancer Ther. 2020.
PMID: 31974273
Free PMC article.
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Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.
Joshi S, Singh AR, Zulcic M, Bao L, Messer K, Ideker T, Dutkowski J, Durden DL.
Joshi S, et al. Among authors: zulcic m.
PLoS One. 2014 Apr 25;9(4):e95893. doi: 10.1371/journal.pone.0095893. eCollection 2014.
PLoS One. 2014.
PMID: 24770346
Free PMC article.
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A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.
Joshi S, Singh AR, Zulcic M, Durden DL.
Joshi S, et al. Among authors: zulcic m.
BMC Immunol. 2014 May 7;15:18. doi: 10.1186/1471-2172-15-18.
BMC Immunol. 2014.
PMID: 24886428
Free PMC article.
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PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.
Singh AR, Joshi S, Zulcic M, Alcaraz M, Garlich JR, Morales GA, Cho YJ, Bao L, Levy ML, Newbury R, Malicki D, Messer K, Crawford J, Durden DL.
Singh AR, et al. Among authors: zulcic m.
PLoS One. 2016 Mar 3;11(3):e0150836. doi: 10.1371/journal.pone.0150836. eCollection 2016.
PLoS One. 2016.
PMID: 26938241
Free PMC article.
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Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.
Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood JS, Durden DL.
Joshi S, et al. Among authors: zulcic m.
PLoS One. 2017 Aug 17;12(8):e0182851. doi: 10.1371/journal.pone.0182851. eCollection 2017.
PLoS One. 2017.
PMID: 28817691
Free PMC article.
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