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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. Zu T, et al. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4968-77. doi: 10.1073/pnas.1315438110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248382 Free PMC article. Clinical Trial.
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Nguyen L, Montrasio F, Pattamatta A, Tusi SK, Bardhi O, Meyer KD, Hayes L, Nakamura K, Banez-Coronel M, Coyne A, Guo S, Laboissonniere LA, Gu Y, Narayanan S, Smith B, Nitsch RM, Kankel MW, Rushe M, Rothstein J, Zu T, Grimm J, Ranum LPW. Nguyen L, et al. Among authors: zu t. Neuron. 2020 Feb 19;105(4):645-662.e11. doi: 10.1016/j.neuron.2019.11.007. Epub 2019 Dec 9. Neuron. 2020. PMID: 31831332 Free PMC article.
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Nguyen L, Laboissonniere LA, Guo S, Pilotto F, Scheidegger O, Oestmann A, Hammond JW, Li H, Hyysalo A, Peltola R, Pattamatta A, Zu T, Voutilainen MH, Gelbard HA, Saxena S, Ranum LPW. Nguyen L, et al. Among authors: zu t. Neuron. 2020 Nov 25;108(4):784-796.e3. doi: 10.1016/j.neuron.2020.09.009. Epub 2020 Oct 5. Neuron. 2020. PMID: 33022226 Free PMC article.
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion.
Pletnikova O, Sloane KL, Renton AE, Traynor BJ, Crain BJ, Reid T, Zu T, Ranum LP, Troncoso JC, Rabins PV, Onyike CU. Pletnikova O, et al. Among authors: zu t. Neurobiol Aging. 2014 Oct;35(10):2419.e17-21. doi: 10.1016/j.neurobiolaging.2014.04.009. Epub 2014 Apr 18. Neurobiol Aging. 2014. PMID: 24819148 Free PMC article. Clinical Trial.
RAN Translation in Huntington Disease.
Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. Bañez-Coronel M, et al. Among authors: zu t. Neuron. 2015 Nov 18;88(4):667-77. doi: 10.1016/j.neuron.2015.10.038. Neuron. 2015. PMID: 26590344 Free PMC article.
60 results