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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J. Roumelioti P, et al. Among authors: zoumpoulakis p. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2. Bioorg Med Chem Lett. 2002. PMID: 12182875
Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
Politi AP, Zervou MV, Triantafyllidi H, Zoumpoulakis PG, Mavromoustakos TM, Zoga AA, Moutevelis-Minakakis P, Kokotos G, Iliodromitis EK, Kremastinos DT. Politi AP, et al. Among authors: zoumpoulakis pg. J Renin Angiotensin Aldosterone Syst. 2010 Jun;11(2):103-10. doi: 10.1177/1470320310365016. Epub 2010 Mar 31. J Renin Angiotensin Aldosterone Syst. 2010. PMID: 20357048 Free article.
Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity.
Moutevelis-Minakakis P, Papavassilopoulou E, Michas G, Georgikopoulou K, Ragoussi ME, Neophytou N, Zoumpoulakis P, Mavromoustakos T, Hadjipavlou-Litina D. Moutevelis-Minakakis P, et al. Among authors: zoumpoulakis p. Bioorg Med Chem. 2011 May 1;19(9):2888-902. doi: 10.1016/j.bmc.2011.03.044. Epub 2011 Apr 1. Bioorg Med Chem. 2011. PMID: 21507662
106 results