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The bs-YHEDA peptide protects the brains of senile mice and thus recovers intelligence by reducing iron and free radicals.
Gao X, Wang Z, Xiong L, Wu F, Gan X, Liu J, Huang X, Liu J, Tang L, Li Y, Huang J, Huang Y, Li W, Zeng H, Ban Y, Chen T, He S, Lin A, Han F, Guo X, Yu Q, Shu W, Zhang B, Zou R, Zhou Y, Chen Y, Tian H, Wei W, Zhang Z, Wei C, Wei Y, Liu H, Yao H, Chen Q, Zou Z. Gao X, et al. Among authors: zou z, zou r. Free Radic Biol Med. 2022 Sep;190:216-225. doi: 10.1016/j.freeradbiomed.2022.08.014. Epub 2022 Aug 13. Free Radic Biol Med. 2022. PMID: 35970250
The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer's disease.
Zou Z, Shen Q, Pang Y, Li X, Chen Y, Wang X, Luo X, Wu Z, Bao Z, Zhang J, Liang J, Kong L, Yan L, Xiong L, Zhu T, Yuan S, Wang M, Cai K, Yao Y, Wu J, Jiang Y, Liu H, Liu J, Zhou Y, Dong Q, Wang W, Zhu K, Li L, Lou Y, Wang H, Li Y, Lin H. Zou Z, et al. Drug Deliv Transl Res. 2019 Feb;9(1):394-403. doi: 10.1007/s13346-018-0579-4. Drug Deliv Transl Res. 2019. PMID: 30136122
Using the synthesized peptide HAYED (5) to protect the brain against iron catalyzed radical attack in a naturally senescence Kunming mouse model.
Zou Z, Cai J, Zhong A, Zhou Y, Wang Z, Wu Z, Yang Y, Li X, Cheng X, Tan J, Fan Y, Zhang X, Lu Y, Zhou Y, Yang L, Zhang C, Zhao Q, Fu D, Shen Q, Chen J, Bai S, Wu L, Chen Y, Chen X, Chen J, Zheng H, Wang H, Lou Y, Ding Y, Shen S, Ye Y, Chen L, Lin Y, Huang J, Zou K, Zhang J, Bian B, Huang C, Rong C, Dai L, Xu Y, Cheng L, Chen Y, Luo Y, Zhang S, Li L. Zou Z, et al. Among authors: zou k. Free Radic Biol Med. 2019 Jan;130:458-470. doi: 10.1016/j.freeradbiomed.2018.11.014. Epub 2018 Nov 15. Free Radic Biol Med. 2019. PMID: 30448512
Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice.
Zou Z, Shao S, Zou R, Qi J, Chen L, Zhang H, Shen Q, Yang Y, Ma L, Guo R, Li H, Tian H, Li P, Yu M, Wang L, Kong W, Li C, Yu Z, Huang Y, Chen L, Shao Q, Gao X, Chen X, Zhang Z, Yan J, Shao X, Pan R, Xu L, Fang J, Zhao L, Huang Y, Li A, Zhang Y, Huang W, Tian K, Hu M, Xie L, Wu L, Wu Y, Luo Z, Xiao W, Ma S, Wang J, Huang K, He S, Yang F, Zhou S, Jia M, Zhang H, Lu H, Wang X, Tan J. Zou Z, et al. Among authors: zou r. Alzheimers Dement (N Y). 2019 Nov 6;5:717-731. doi: 10.1016/j.trci.2019.07.013. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31921964 Free PMC article.
Epigenetics in Alzheimer's Disease.
Gao X, Chen Q, Yao H, Tan J, Liu Z, Zhou Y, Zou Z. Gao X, et al. Among authors: zou z. Front Aging Neurosci. 2022 Jun 23;14:911635. doi: 10.3389/fnagi.2022.911635. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35813941 Free PMC article. Review.
4,265 results