Zou AR - Search Results

1

Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain.

Niu HL, Liu YN, Xue DQ, Dong LY, Liu HJ, Wang J, Zheng YL, Zou AR, Shao LM, Wang K. Niu HL, et al. Among authors: zou ar. Acta Pharmacol Sin. 2021 Aug;42(8):1235-1247. doi: 10.1038/s41401-021-00682-9. Epub 2021 Jun 8. Acta Pharmacol Sin. 2021. PMID: 34103689 Free PMC article.

2

Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel.

Dong X, Liu Y, Niu H, Wang G, Dong L, Zou A, Wang K. Dong X, et al. J Pharmacol Sci. 2019 Jul;140(3):284-290. doi: 10.1016/j.jphs.2019.08.001. Epub 2019 Aug 14. J Pharmacol Sci. 2019. PMID: 31481348 Free article.

3

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16. Bioorg Med Chem Lett. 2015. PMID: 26112439

4

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Bregman H, Berry L, Buchanan JL, Chen A, Du B, Feric E, Hierl M, Huang L, Immke D, Janosky B, Johnson D, Li X, Ligutti J, Liu D, Malmberg A, Matson D, McDermott J, Miu P, Nguyen HN, Patel VF, Waldon D, Wilenkin B, Zheng XM, Zou A, McDonough SI, DiMauro EF. Bregman H, et al. J Med Chem. 2011 Jul 14;54(13):4427-45. doi: 10.1021/jm200018k. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21634377

5

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Murray JK, Ligutti J, Liu D, Zou A, Poppe L, Li H, Andrews KL, Moyer BD, McDonough SI, Favreau P, Stöcklin R, Miranda LP. Murray JK, et al. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19. J Med Chem. 2015. PMID: 25658507

6

Electropharmacological properties of telmisartan in blocking hKv1.5 and HERG potassium channels expressed on Xenopus laevis oocytes.

Tu DN, Liao YH, Zou AR, Du YM, Run Q, Wang XP, Li L. Tu DN, et al. Among authors: zou ar. Acta Pharmacol Sin. 2008 Aug;29(8):913-22. doi: 10.1111/j.1745-7254.2008.00839.x. Acta Pharmacol Sin. 2008. PMID: 18664324

7

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.

Moyer BD, Murray JK, Ligutti J, Andrews K, Favreau P, Jordan JB, Lee JH, Liu D, Long J, Sham K, Shi L, Stöcklin R, Wu B, Yin R, Yu V, Zou A, Biswas K, Miranda LP. Moyer BD, et al. PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018. PLoS One. 2018. PMID: 29723257 Free PMC article.

8

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

Murray JK, Long J, Zou A, Ligutti J, Andrews KL, Poppe L, Biswas K, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. J Med Chem. 2016 Mar 24;59(6):2704-17. doi: 10.1021/acs.jmedchem.5b01947. Epub 2016 Mar 10. J Med Chem. 2016. PMID: 26890998

9

Discovery of Tarantula Venom-Derived Na_V1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Wu B, Murray JK, Andrews KL, Sham K, Long J, Aral J, Ligutti J, Amagasu S, Liu D, Zou A, Min X, Wang Z, Ilch CP, Kornecook TJ, Lin MJ, Be X, Miranda LP, Moyer BD, Biswas K. Wu B, et al. J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22. J Med Chem. 2018. PMID: 30346167

10

A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT₁ receptors.

Wu H, Wang Y, Wang G, Qiu Z, Hu X, Zhang H, Yan X, Ke F, Zou A, Wang M, Liao Y, Chen X. Wu H, et al. Br J Pharmacol. 2020 Jan;177(2):402-419. doi: 10.1111/bph.14875. Epub 2019 Dec 12. Br J Pharmacol. 2020. PMID: 31625597 Free PMC article.

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