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Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy.
Zorzopulos J, Opal SM, Hernando-Insúa A, Rodriguez JM, Elías F, Fló J, López RA, Chasseing NA, Lux-Lantos VA, Coronel MF, Franco R, Montaner AD, Horn DL. Zorzopulos J, et al. World J Stem Cells. 2017 Mar 26;9(3):45-67. doi: 10.4252/wjsc.v9.i3.45. World J Stem Cells. 2017. PMID: 28396715 Free PMC article. Review.
IMT504, the prototype of the immunostimulatory oligonucleotides of the PyNTTTTGT class, increases the number of progenitors of mesenchymal stem cells both in vitro and in vivo: potential use in tissue repair therapy.
Hernando Insúa A, Montaner AD, Rodriguez JM, Elías F, Fló J, López RA, Zorzopulos J, Hofer EL, Chasseing NA. Hernando Insúa A, et al. Among authors: zorzopulos j. Stem Cells. 2007 Apr;25(4):1047-54. doi: 10.1634/stemcells.2006-0479. Stem Cells. 2007. PMID: 17420228
Non-clinical safety studies of IMT504, a unique non-CpG oligonucleotide.
Franco R, Rodriguez JM, Elías F, Hernando-Insúa A, Fló J, López R, Nagle C, Lago N, Zorzopulos J, Horn DL, Montaner AD. Franco R, et al. Among authors: zorzopulos j. Nucleic Acid Ther. 2014 Aug;24(4):267-82. doi: 10.1089/nat.2013.0479. Epub 2014 Apr 10. Nucleic Acid Ther. 2014. PMID: 24720569 Free PMC article.
Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers.
Bianchi MS, Hernando-Insúa A, Chasseing NA, Rodríguez JM, Elías F, Lago N, Zorzopulos J, Libertun C, Montaner AD, Lux-Lantos VA. Bianchi MS, et al. Among authors: zorzopulos j. Diabetologia. 2010 Jun;53(6):1184-9. doi: 10.1007/s00125-010-1694-z. Epub 2010 Mar 11. Diabetologia. 2010. PMID: 20221823
PyNTTTTGT and CpG immunostimulatory oligonucleotides: effect on granulocyte/monocyte colony-stimulating factor (GM-CSF) secretion by human CD56+ (NK and NKT) cells.
Rodriguez JM, Marchicio J, López M, Ziblat A, Elias F, Fló J, López RA, Horn D, Zorzopulos J, Montaner AD. Rodriguez JM, et al. Among authors: zorzopulos j. PLoS One. 2015 Feb 23;10(2):e0117484. doi: 10.1371/journal.pone.0117484. eCollection 2015. PLoS One. 2015. PMID: 25706946 Free PMC article.
Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire.
Montaner AD, Denichilo A, Rodríguez JM, Fló J, López RA, Pontoriero A, Savy V, Baumeister E, Frank R, Zorzopulos J, Elías F. Montaner AD, et al. Among authors: zorzopulos j. Nucleic Acid Ther. 2011 Aug;21(4):265-74. doi: 10.1089/nat.2011.0284. Epub 2011 Jul 5. Nucleic Acid Ther. 2011. PMID: 21793787
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