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Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.
di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, Consiglio A. di Domenico A, et al. Among authors: zorzano a. Stem Cell Reports. 2019 Feb 12;12(2):213-229. doi: 10.1016/j.stemcr.2018.12.011. Epub 2019 Jan 10. Stem Cell Reports. 2019. PMID: 30639209 Free PMC article.
Endoplasmic reticulum stress enters a Nogo zone.
Muñoz JP, Zorzano A. Muñoz JP, et al. Among authors: zorzano a. Sci Transl Med. 2011 Jun 22;3(88):88ps26. doi: 10.1126/scitranslmed.3002708. Sci Transl Med. 2011. PMID: 21697529
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A. Sebastián D, et al. Among authors: zorzano a. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109. Epub 2012 Mar 16. Proc Natl Acad Sci U S A. 2012. PMID: 22427360 Free PMC article.
Mfn2 modulates the UPR and mitochondrial function via repression of PERK.
Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M, Zorzano A. Muñoz JP, et al. Among authors: zorzano a. EMBO J. 2013 Aug 28;32(17):2348-61. doi: 10.1038/emboj.2013.168. Epub 2013 Aug 6. EMBO J. 2013. PMID: 23921556 Free PMC article.
A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells.
Segalés J, Paz JC, Hernández-Alvarez MI, Sala D, Muñoz JP, Noguera E, Pich S, Palacín M, Enríquez JA, Zorzano A. Segalés J, et al. Among authors: zorzano a. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1208-21. doi: 10.1152/ajpendo.00546.2012. Epub 2013 Aug 13. Am J Physiol Endocrinol Metab. 2013. PMID: 23941871 Free article.
Mfn2 modulates the unfolded protein response.
Muñoz JP, Zorzano A. Muñoz JP, et al. Among authors: zorzano a. Cell Cycle. 2014;13(4):491-2. doi: 10.4161/cc.27782. Epub 2014 Jan 13. Cell Cycle. 2014. PMID: 24419149 No abstract available.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A. Sebastián D, et al. Among authors: zorzano a. EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334614 Free PMC article.
373 results