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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M. Zmudzinski M, et al. Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w. Sci Rep. 2023. PMID: 37280236 Free PMC article.
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging.
Rut W, Groborz K, Zhang L, Sun X, Zmudzinski M, Pawlik B, Wang X, Jochmans D, Neyts J, Młynarski W, Hilgenfeld R, Drag M. Rut W, et al. Among authors: zmudzinski m. Nat Chem Biol. 2021 Feb;17(2):222-228. doi: 10.1038/s41589-020-00689-z. Epub 2020 Oct 22. Nat Chem Biol. 2021. PMID: 33093684
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts.
Strub DJ, Talma M, Strub M, Rut W, Zmudzinski M, Brud W, Neyts J, Vangeel L, Zhang L, Sun X, Lv Z, Nayak D, Olsen SK, Hilgenfeld R, Jochmans D, Drąg M. Strub DJ, et al. Among authors: zmudzinski m. Sci Rep. 2022 Aug 20;12(1):14230. doi: 10.1038/s41598-022-18676-w. Sci Rep. 2022. PMID: 35987981 Free PMC article.
Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding.
Perlinska AP, Stasiulewicz A, Nguyen ML, Swiderska K, Zmudzinski M, Maksymiuk AW, Drag M, Sulkowska JI. Perlinska AP, et al. Among authors: zmudzinski m. PLoS Comput Biol. 2022 Nov 21;18(11):e1010667. doi: 10.1371/journal.pcbi.1010667. eCollection 2022 Nov. PLoS Comput Biol. 2022. PMID: 36409737 Free PMC article.
Imaging of proteases using activity-based probes.
Zmudzinski M, Malon O, Poręba M, Drąg M. Zmudzinski M, et al. Curr Opin Chem Biol. 2023 Jun;74:102299. doi: 10.1016/j.cbpa.2023.102299. Epub 2023 Apr 7. Curr Opin Chem Biol. 2023. PMID: 37031620 Review.
28 results