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Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. Shi Y, et al. Among authors: zlokovic bv. Nat Med. 2018 Mar;24(3):313-325. doi: 10.1038/nm.4490. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400714 Free PMC article.
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Bell RD, et al. Among authors: zlokovic bv. Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087. Nature. 2012. PMID: 22622580 Free PMC article.
Pericyte loss influences Alzheimer-like neurodegeneration in mice.
Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Sagare AP, et al. Among authors: zlokovic bv. Nat Commun. 2013;4:2932. doi: 10.1038/ncomms3932. Nat Commun. 2013. PMID: 24336108 Free PMC article. Retracted.
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. Winkler EA, et al. Among authors: zlokovic bv. Nat Neurosci. 2015 Apr;18(4):521-530. doi: 10.1038/nn.3966. Epub 2015 Mar 2. Nat Neurosci. 2015. PMID: 25730668 Free PMC article.
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. Zhao Z, et al. Among authors: zlokovic bv. Nat Neurosci. 2015 Jul;18(7):978-87. doi: 10.1038/nn.4025. Epub 2015 May 25. Nat Neurosci. 2015. PMID: 26005850 Free PMC article.
Establishment and Dysfunction of the Blood-Brain Barrier.
Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. Zhao Z, et al. Among authors: zlokovic bv. Cell. 2015 Nov 19;163(5):1064-1078. doi: 10.1016/j.cell.2015.10.067. Cell. 2015. PMID: 26590417 Free PMC article. Review.
334 results