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Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E. Malwal SR, et al. Among authors: zimmerman md. J Med Chem. 2023 Jun 8;66(11):7553-7569. doi: 10.1021/acs.jmedchem.3c00398. Epub 2023 May 26. J Med Chem. 2023. PMID: 37235809 Free PMC article.
The association between sterilizing activity and drug distribution into tuberculosis lesions.
Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Among authors: zimmerman md. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.
Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent.
Gallardo-Macias R, Kumar P, Jaskowski M, Richmann T, Shrestha R, Russo R, Singleton E, Zimmerman MD, Ho HP, Dartois V, Connell N, Alland D, Freundlich JS. Gallardo-Macias R, et al. Among authors: zimmerman md. Bioorg Med Chem Lett. 2019 Feb 15;29(4):601-606. doi: 10.1016/j.bmcl.2018.12.053. Epub 2018 Dec 24. Bioorg Med Chem Lett. 2019. PMID: 30600207 Free PMC article.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MA, Su H, Trujillo C, Ehrt S, Schnappinger D, Dartois V. Gengenbacher M, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02479-19. doi: 10.1128/AAC.02479-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32041718 Free PMC article.
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques.
Winchell CG, Mishra BB, Phuah JY, Saqib M, Nelson SJ, Maiello P, Causgrove CM, Ameel CL, Stein B, Borish HJ, White AG, Klein EC, Zimmerman MD, Dartois V, Lin PL, Sassetti CM, Flynn JL. Winchell CG, et al. Among authors: zimmerman md. Front Immunol. 2020 May 12;11:891. doi: 10.3389/fimmu.2020.00891. eCollection 2020. Front Immunol. 2020. PMID: 32477361 Free PMC article.
Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus.
Negatu DA, Beuchel A, Madani A, Alvarez N, Chen C, Aragaw WW, Zimmerman MD, Laleu B, Gengenbacher M, Dartois V, Imming P, Dick T. Negatu DA, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0067621. doi: 10.1128/AAC.00676-21. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34001512 Free PMC article.
92 results