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Predicting and tuning physicochemical properties in lead optimization: amine basicities.
Morgenthaler M, Schweizer E, Hoffmann-Röder A, Benini F, Martin RE, Jaeschke G, Wagner B, Fischer H, Bendels S, Zimmerli D, Schneider J, Diederich F, Kansy M, Müller K. Morgenthaler M, et al. Among authors: zimmerli d. ChemMedChem. 2007 Aug;2(8):1100-15. doi: 10.1002/cmdc.200700059. ChemMedChem. 2007. PMID: 17530727 Review.
Strain-accelerated formation of chiral, optically active buta-1,3-dienes.
Chiu M, Tchitchanov BH, Zimmerli D, Sanhueza IA, Schoenebeck F, Trapp N, Schweizer WB, Diederich F. Chiu M, et al. Among authors: zimmerli d. Angew Chem Int Ed Engl. 2015 Jan 2;54(1):349-54. doi: 10.1002/anie.201409289. Epub 2014 Nov 26. Angew Chem Int Ed Engl. 2015. PMID: 25425560
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Pinard E, Alberati D, Bender M, Borroni E, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Norcross RD, Schmid P, Wermuth R, Zimmerli D. Pinard E, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6960-5. doi: 10.1016/j.bmcl.2010.09.124. Epub 2010 Oct 7. Bioorg Med Chem Lett. 2010. PMID: 20974532
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Nettekoven M, Norcross RD, Puellmann B, Schmid P, Schmitt S, Stalder H, Wermuth R, Wettstein JG, Zimmerli D. Pinard E, et al. Among authors: zimmerli d. J Med Chem. 2010 Jun 24;53(12):4603-14. doi: 10.1021/jm100210p. J Med Chem. 2010. PMID: 20491477
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Alberati D, Hainzl D, Jolidon S, Krafft EA, Kurt A, Maier A, Pinard E, Thomas AW, Zimmerli D. Alberati D, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4311-5. doi: 10.1016/j.bmcl.2006.05.058. Epub 2006 Jun 6. Bioorg Med Chem Lett. 2006. PMID: 16757170
Aminomethylpyridines as DPP-IV inhibitors.
Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Zimmerli D, Boehringer M, Steger M, Loeffler BM. Peters JU, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3579-80. doi: 10.1016/j.bmcl.2004.04.049. Bioorg Med Chem Lett. 2004. PMID: 15177478
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