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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.
Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG. Mitchem JB, et al. Among authors: zhu y. Cancer Res. 2013 Feb 1;73(3):1128-41. doi: 10.1158/0008-5472.CAN-12-2731. Epub 2012 Dec 5. Cancer Res. 2013. PMID: 23221383 Free PMC article.
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC.
Baer JM, Zuo C, Kang LI, de la Lastra AA, Borcherding NC, Knolhoff BL, Bogner SJ, Zhu Y, Yang L, Laurent J, Lewis MA, Zhang N, Kim KW, Fields RC, Yokoyama WM, Mills JC, Ding L, Randolph GJ, DeNardo DG. Baer JM, et al. Among authors: zhu y. Nat Immunol. 2023 Sep;24(9):1443-1457. doi: 10.1038/s41590-023-01579-x. Epub 2023 Aug 10. Nat Immunol. 2023. PMID: 37563309 Free PMC article.
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