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Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Liu P, et al. Among authors: zhu ll. Nature. 2017 Jun 1;546(7656):107-112. doi: 10.1038/nature22342. Epub 2017 May 24. Nature. 2017. PMID: 28538730 Free PMC article.
Proresorptive actions of FSH and bone loss.
Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, Sun L. Zaidi M, et al. Among authors: zhu ll. Ann N Y Acad Sci. 2007 Nov;1116:376-82. doi: 10.1196/annals.1402.056. Ann N Y Acad Sci. 2007. PMID: 18083939 Review.
Blocking FSH action attenuates osteoclastogenesis.
Zhu LL, Tourkova I, Yuen T, Robinson LJ, Bian Z, Zaidi M, Blair HC. Zhu LL, et al. Biochem Biophys Res Commun. 2012 May 25;422(1):54-8. doi: 10.1016/j.bbrc.2012.04.104. Epub 2012 Apr 27. Biochem Biophys Res Commun. 2012. PMID: 22561017 Free PMC article.
FSH directly regulates bone mass.
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. Sun L, et al. Among authors: zhu ll. Cell. 2006 Apr 21;125(2):247-60. doi: 10.1016/j.cell.2006.01.051. Cell. 2006. PMID: 16630814 Free article.
Regulation of FSH receptor promoter activation in the osteoclast.
Zaidi S, Zhu LL, Mali R, Iqbal J, Yang G, Zaidi M, Sun L. Zaidi S, et al. Among authors: zhu ll. Biochem Biophys Res Commun. 2007 Oct 5;361(4):910-5. doi: 10.1016/j.bbrc.2007.07.081. Epub 2007 Jul 24. Biochem Biophys Res Commun. 2007. PMID: 17681281
Further evidence for direct pro-resorptive actions of FSH.
Sun L, Zhang Z, Zhu LL, Peng Y, Liu X, Li J, Agrawal M, Robinson LJ, Iqbal J, Blair HC, Zaidi M. Sun L, et al. Among authors: zhu ll. Biochem Biophys Res Commun. 2010 Mar 26;394(1):6-11. doi: 10.1016/j.bbrc.2010.02.113. Epub 2010 Feb 19. Biochem Biophys Res Commun. 2010. PMID: 20171951 Free PMC article.
Vitamin C prevents hypogonadal bone loss.
Zhu LL, Cao J, Sun M, Yuen T, Zhou R, Li J, Peng Y, Moonga SS, Guo L, Mechanick JI, Iqbal J, Peng L, Blair HC, Bian Z, Zaidi M. Zhu LL, et al. PLoS One. 2012;7(10):e47058. doi: 10.1371/journal.pone.0047058. Epub 2012 Oct 8. PLoS One. 2012. PMID: 23056580 Free PMC article.
503 results