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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB. Yang L, et al. Among authors: zhu h. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846099
Construction of a versatile expression library for all human single-pass transmembrane proteins for receptor pairings by high throughput screening.
Yang W, Padkjær SB, Wang J, Sun Z, Shan B, Yang L, Chen H, Kang L, Madsen D, Li X, Shen C, Yu B, Zhu H, Chao TY, Cao Z, Li D, Liu W, Du Y, Xu J, Hao D, Xu F, Peng L, Li T, Wang L, Li L, Xing H, Liu D, Liu Z, Guan Z, Wang W, Cheng H, Østergaard H, Chang C, Yang Z, Boel E, Su J. Yang W, et al. Among authors: zhu h. J Biotechnol. 2017 Oct 20;260:18-30. doi: 10.1016/j.jbiotec.2017.08.023. Epub 2017 Sep 1. J Biotechnol. 2017. PMID: 28867483
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, Johansson E, Røder G, Rasch MG, Johnsen LB, Egebjerg T, Lund S, Rahbek-Nielsen H, Gandhi PS, Lamberth K, Loftager M, Andersen LM, Bonde AC, Stavenuiter F, Madsen DE, Li X, Holm TL, Ley CD, Thygesen P, Zhu H, Zhou R, Thorn K, Yang Z, Hermit MB, Bjelke JR, Hansen BG, Hilden I. Østergaard H, et al. Among authors: zhu h. Blood. 2021 Oct 7;138(14):1258-1268. doi: 10.1182/blood.2020010331. Blood. 2021. PMID: 34077951 Free PMC article.
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane.
Shi W, Cai Y, Zhu H, Peng H, Voyer J, Rits-Volloch S, Cao H, Mayer ML, Song K, Xu C, Lu J, Zhang J, Chen B. Shi W, et al. Among authors: zhu h. Nature. 2023 Jul;619(7969):403-409. doi: 10.1038/s41586-023-06273-4. Epub 2023 Jun 7. Nature. 2023. PMID: 37285872
Structural impact on SARS-CoV-2 spike protein by D614G substitution.
Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh RM Jr, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B. Zhang J, et al. Among authors: zhu h. Science. 2021 Apr 30;372(6541):525-530. doi: 10.1126/science.abf2303. Epub 2021 Mar 16. Science. 2021. PMID: 33727252 Free PMC article.
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.
Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM Jr, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Cai Y, et al. Among authors: zhu h. Science. 2021 Aug 6;373(6555):642-648. doi: 10.1126/science.abi9745. Epub 2021 Jun 24. Science. 2021. PMID: 34168070 Free PMC article.
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