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A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Among authors: zhu c. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
Prion protein and prion disease at a glance.
Zhu C, Aguzzi A. Zhu C, et al. J Cell Sci. 2021 Sep 1;134(17):jcs245605. doi: 10.1242/jcs.245605. Epub 2021 Sep 2. J Cell Sci. 2021. PMID: 34472604
Protective anti-prion antibodies in human immunoglobulin repertoires.
Senatore A, Frontzek K, Emmenegger M, Chincisan A, Losa M, Reimann R, Horny G, Guo J, Fels S, Sorce S, Zhu C, George N, Ewert S, Pietzonka T, Hornemann S, Aguzzi A. Senatore A, et al. Among authors: zhu c. EMBO Mol Med. 2020 Sep 7;12(9):e12739. doi: 10.15252/emmm.202012739. Epub 2020 Aug 10. EMBO Mol Med. 2020. PMID: 32776637 Free PMC article.
Five questions on prion diseases.
Aguzzi A, Zhu C. Aguzzi A, et al. Among authors: zhu c. PLoS Pathog. 2012;8(5):e1002651. doi: 10.1371/journal.ppat.1002651. Epub 2012 May 3. PLoS Pathog. 2012. PMID: 22570608 Free PMC article. No abstract available.
The immunobiology of prion diseases.
Aguzzi A, Nuvolone M, Zhu C. Aguzzi A, et al. Among authors: zhu c. Nat Rev Immunol. 2013 Dec;13(12):888-902. doi: 10.1038/nri3553. Epub 2013 Nov 5. Nat Rev Immunol. 2013. PMID: 24189576 Review.
A neuroprotective role for microglia in prion diseases.
Zhu C, Herrmann US, Falsig J, Abakumova I, Nuvolone M, Schwarz P, Frauenknecht K, Rushing EJ, Aguzzi A. Zhu C, et al. J Exp Med. 2016 May 30;213(6):1047-59. doi: 10.1084/jem.20151000. Epub 2016 May 16. J Exp Med. 2016. PMID: 27185853 Free PMC article.
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