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Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens.
Kim SH, Steere L, Zhang YK, McGregor C, Hahne C, Zhou Y, Liu C, Cai Y, Zhou H, Chen X, Puumala E, Duncan D, Wright GD, Liu CT, Whitesell L, Cowen LE. Kim SH, et al. Among authors: zhou h, zhou y. ACS Chem Biol. 2022 Jun 17;17(6):1343-1350. doi: 10.1021/acschembio.2c00257. Epub 2022 May 18. ACS Chem Biol. 2022. PMID: 35584803 Free PMC article.
Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides.
Liu C, Steere L, McGregor C, Frederick BH, Pastoor T, Zhou Y, Liu CT, Cai Y, Zhou H, Xu M, Wang J, Kim SH, Whitesell L, Cowen LE, Zhang YK. Liu C, et al. Among authors: zhou h, zhou y. Bioorg Med Chem Lett. 2021 Jul 1;43:128089. doi: 10.1016/j.bmcl.2021.128089. Epub 2021 May 5. Bioorg Med Chem Lett. 2021. PMID: 33964438
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease.
Duan M, Kazmierski W, Crosby R, Gartland M, Ji J, Tallant M, Wang A, Hamatake R, Wright L, Wu M, Zhang YK, Ding CZ, Li X, Liu Y, Zhang S, Zhou Y, Plattner JJ, Baker SJ. Duan M, et al. Among authors: zhou y. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2993-6. doi: 10.1016/j.bmcl.2012.02.039. Epub 2012 Feb 22. Bioorg Med Chem Lett. 2012. PMID: 22425454
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L. Kazmierski WM, et al. Among authors: zhou y. J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22471376
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. Sonoiki E, et al. Among authors: zhou y. Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574. Nat Commun. 2017. PMID: 28262680 Free PMC article.
Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.
Akama T, Dong C, Virtucio C, Sullivan D, Zhou Y, Zhang YK, Rock F, Freund Y, Liu L, Bu W, Wu A, Fan XQ, Jarnagin K. Akama T, et al. Among authors: zhou y. J Pharmacol Exp Ther. 2013 Dec;347(3):615-25. doi: 10.1124/jpet.113.207662. Epub 2013 Sep 18. J Pharmacol Exp Ther. 2013. PMID: 24049062
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