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Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. Zhou GB, et al. Blood. 2007 Apr 15;109(8):3441-50. doi: 10.1182/blood-2006-06-032250. Epub 2006 Dec 29. Blood. 2007. PMID: 17197433 Free PMC article.
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.
Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. Wang YY, et al. Among authors: zhou gb. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1104-9. doi: 10.1073/pnas.0408831102. Epub 2005 Jan 13. Proc Natl Acad Sci U S A. 2005. PMID: 15650049 Free PMC article.
171 results