Zhong L - Search Results

1

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.

Zhong L, Li Y, Xiong L, Wang W, Wu M, Yuan T, Yang W, Tian C, Miao Z, Wang T, Yang S. Zhong L, et al. Signal Transduct Target Ther. 2021 May 31;6(1):201. doi: 10.1038/s41392-021-00572-w. Signal Transduct Target Ther. 2021. PMID: 34054126 Free PMC article. Review.

2

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.

Xie QQ, Zhong L, Pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY. Xie QQ, et al. Among authors: zhong l. Eur J Med Chem. 2011 Sep;46(9):3675-80. doi: 10.1016/j.ejmech.2011.05.031. Epub 2011 May 25. Eur J Med Chem. 2011. PMID: 21641696

3

A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method.

Zhong L, Ma CY, Zhang H, Yang LJ, Wan HL, Xie QQ, Li LL, Yang SY. Zhong L, et al. Comput Biol Med. 2011 Nov;41(11):1006-13. doi: 10.1016/j.compbiomed.2011.08.009. Epub 2011 Sep 14. Comput Biol Med. 2011. PMID: 21924412

4

Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.

Zhou JP, Chen X, Feng S, Luo SD, Pan YL, Zhong L, Ji P, Wang ZR, Ma S, Li LL, Wei YQ, Yang SY. Zhou JP, et al. Among authors: zhong l. PLoS One. 2011;6(12):e28930. doi: 10.1371/journal.pone.0028930. Epub 2011 Dec 14. PLoS One. 2011. PMID: 22194952 Free PMC article.

5

SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro and in vivo.

Pan Y, Xu Y, Feng S, Luo S, Zheng R, Yang J, Wang L, Zhong L, Yang HY, Wang BL, Yu Y, Liu J, Cao Z, Wang X, Ji P, Wang Z, Chen X, Zhang S, Wei YQ, Yang SY. Pan Y, et al. Among authors: zhong l. Mol Cancer Ther. 2012 Apr;11(4):952-62. doi: 10.1158/1535-7163.MCT-11-0679. Epub 2012 Feb 8. Mol Cancer Ther. 2012. PMID: 22319204

6

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: zhong l. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

7

Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking.

Di-wu L, Li LL, Wang WJ, Xie HZ, Yang J, Zhang CH, Huang Q, Zhong L, Feng S, Yang SY. Di-wu L, et al. Among authors: zhong l. J Mol Graph Model. 2012 Jun;36:42-7. doi: 10.1016/j.jmgm.2012.03.004. Epub 2012 Mar 26. J Mol Graph Model. 2012. PMID: 22516037

8

Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.

Yang J, Wang LJ, Liu JJ, Zhong L, Zheng RL, Xu Y, Ji P, Zhang CH, Wang WJ, Lin XD, Li LL, Wei YQ, Yang SY. Yang J, et al. Among authors: zhong l. J Med Chem. 2012 Dec 13;55(23):10685-99. doi: 10.1021/jm301365e. Epub 2012 Nov 16. J Med Chem. 2012. PMID: 23116168

9

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Chen X, Ji P, Yang HW, Yang LL, Zhou S, Zhong L, Ma S, Fu XY, Zhou C, Li GB, Zheng MW, Wei YQ, Yang SY. Chen X, et al. Among authors: zhong l. Cell Physiol Biochem. 2013;32(1):138-53. doi: 10.1159/000350123. Epub 2013 Jul 12. Cell Physiol Biochem. 2013. PMID: 23867251 Free article.

10

A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.

Zhong L, Fu XY, Zou C, Yang LL, Zhou S, Yang J, Tang Y, Cheng C, Li LL, Xiang R, Chen LJ, Chen YZ, Wei YQ, Yang SY. Zhong L, et al. Int J Cancer. 2014 Dec 15;135(12):2972-83. doi: 10.1002/ijc.28944. Epub 2014 May 12. Int J Cancer. 2014. PMID: 24789676 Free article.

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