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Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.
Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins KJ, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze LA, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure SP, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields RC, Flavell RA. Chiorazzi M, et al. Among authors: zheng y. J Immunother Cancer. 2023 Jul;11(7):e006921. doi: 10.1136/jitc-2023-006921. J Immunother Cancer. 2023. PMID: 37487666 Free PMC article.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Zhu S, et al. Among authors: zheng y. Nature. 2017 Jun 29;546(7660):667-670. doi: 10.1038/nature22967. Epub 2017 Jun 21. Nature. 2017. PMID: 28636595 Free PMC article.
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL. Ring NG, et al. Among authors: zheng y. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20. Proc Natl Acad Sci U S A. 2017. PMID: 29158380 Free PMC article.
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.
Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N. Pan W, et al. Among authors: zheng y. Nat Commun. 2015 May 12;6:7096. doi: 10.1038/ncomms8096. Nat Commun. 2015. PMID: 25963922 Free article.
Nlrp6 regulates intestinal antiviral innate immunity.
Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Wang P, et al. Among authors: zheng y. Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. Epub 2015 Oct 22. Science. 2015. PMID: 26494172 Free PMC article.
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