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Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy.
Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Sun Y, et al. Among authors: zheng l. Sci Transl Med. 2021 Jul 28;13(604):eabc8922. doi: 10.1126/scitranslmed.abc8922. Sci Transl Med. 2021. PMID: 34321321 Free PMC article.
B7-h2 is a costimulatory ligand for CD28 in human.
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. Yao S, et al. Among authors: zheng l. Immunity. 2011 May 27;34(5):729-40. doi: 10.1016/j.immuni.2011.03.014. Epub 2011 Apr 28. Immunity. 2011. PMID: 21530327 Free PMC article.
B7-H5 costimulates human T cells via CD28H.
Zhu Y, Yao S, Iliopoulou BP, Han X, Augustine MM, Xu H, Phennicie RT, Flies SJ, Broadwater M, Ruff W, Taube JM, Zheng L, Luo L, Zhu G, Chen J, Chen L. Zhu Y, et al. Among authors: zheng l. Nat Commun. 2013;4:2043. doi: 10.1038/ncomms3043. Nat Commun. 2013. PMID: 23784006 Free PMC article.
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.
Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Wang J, et al. Among authors: zheng l. Cell. 2019 Jan 10;176(1-2):334-347.e12. doi: 10.1016/j.cell.2018.11.010. Epub 2018 Dec 20. Cell. 2019. PMID: 30580966 Free PMC article.
The CD8α-PILRα interaction maintains CD8+ T cell quiescence.
Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. Zheng L, et al. Science. 2022 May 27;376(6596):996-1001. doi: 10.1126/science.aaz8658. Epub 2022 May 26. Science. 2022. PMID: 35617401
PD-1H/VISTA mediates immune evasion in acute myeloid leukemia.
Kim TK, Han X, Hu Q, Vandsemb EN, Fielder CM, Hong J, Kim KW, Mason EF, Plowman RS, Wang J, Wang Q, Zhang JP, Badri T, Sanmamed MF, Zheng L, Zhang T, Alawa J, Lee SW, Zeidan AM, Halene S, Pillai MM, Chandhok NS, Lu J, Xu ML, Gore SD, Chen L. Kim TK, et al. Among authors: zheng l. J Clin Invest. 2024 Feb 1;134(3):e164325. doi: 10.1172/JCI164325. J Clin Invest. 2024. PMID: 38060328 Free PMC article.
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